ArticleBrain imaging and behavior2010
Quantitative diffusion tensor imaging tractography metrics are associated with cognitive performance among HIV-infected patients.
Article in Brain imaging and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02571504 (Brain Imaging to Understand HIV-associated Neurocognitive Disorder and Predict Response to Cognitive Training), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Imaging to Understand HIV-associated Neurocognitive Disorder and Predict Response to Cognitive Training
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of Diffusion Tensor Imaging (DTI) in the Diagnosis of HIV-Associated Neurocognitive Disorder (HAND): A Meta-Analysis and a System Review.Frontiers in neurology · 2022Pooled it
- Review
- Review
- Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system.Journal of neuroinflammation · 2024Article
- HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology.International journal of molecular sciences · 2024Review
- Non-classical monocyte levels correlate negatively with HIV-associated cerebral small vessel disease and cognitive performance.Frontiers in cellular and infection microbiology · 2024Observational
- Myelin regulatory factor is a target of individual and interactive effects of HIV-1 Tat and morphine in the striatum and pre-frontal cortex.Journal of neurovirology · 2023Article
- Rich-Club Analysis of Structural Brain Network Alterations in HIV Positive Patients With Fully Suppressed Plasma Viral Loads.Frontiers in neurology · 2022Article
- Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs.Frontiers in cellular and infection microbiology · 2020Review
- White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?Brain research · 2019Review
- White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa.Brain imaging and behavior · 2018Article
- Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment.Brain : a journal of neurology · 2018Article
- Neural response to working memory demand predicts neurocognitive deficits in HIV.Journal of neurovirology · 2018Article
- White Matter Changes in HIV+ Women with a History of Cocaine Dependence.Frontiers in neurology · 2017Article
- Cognitive Impairment and Persistent CNS Injury in Treated HIV.Current HIV/AIDS reports · 2016Review
- The impact of human immune deficiency virus and hepatitis C coinfection on white matter microstructural integrity.Journal of neurovirology · 2016Article
- What can imaging tell us about cognitive impairment and dementia?World journal of radiology · 2016Review
- Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females.Journal of neurovirology · 2016Article
- Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition.Behavioural brain research · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
There have been many studies examining HIV-infection-related alterations of magnetic resonance imaging (MRI) diffusion metrics. However, examining scalar diffusion metrics ignores the orientation aspect of diffusion imaging, which can be captured with tractography. We examined five different tractography metrics obtained from global tractography maps (global tractography FA, average tube length, normalized number of streamtubes, normalized weighted streamtube length, and normalized total number of tubes generated) for differences between HIV positive and negative patients and the association between the metrics and clinical variables of disease severity. We also examined the relationship between these metrics and cognitive performance across a wide range of cognitive domains for the HIV positive and negative patient groups separately. The results demonstrated a significant difference between the groups for global tractography FA (t = 2.13, p = 0.04), but not for any of the other tractography metrics examined (p-value range = 0.39 to 0.95). There were also several significant associations between the tractography metrics and cognitive performance (i.e., tapping rates, switching 1 and 2, verbal interference, mazes; r > or = 0.42) for HIV infected patients. In particular, associations were noted between tractography metrics, speed of processing, fine motor control/speed, and executive function for the HIV-infected patients. These findings suggest that tractography metrics capture clinically relevant information regarding cognitive performance among HIV infected patients and suggests the importance of subtle white matter changes in examining cognitive performance.
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Registered trials
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