ArticleDigestive diseases and sciences2011
CagA-positive Helicobacter pylori strains enhanced coronary atherosclerosis by increasing serum OxLDL and HsCRP in patients with coronary heart disease.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications.Annals of clinical microbiology and antimicrobials · 2025Pooled it
- A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022Pooled it
- Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients.Journal of neurology · 2021Pooled it
- Helicobacter pylori infection contributes to high risk of ischemic stroke: evidence from a meta-analysis.Journal of neurology · 2012Pooled it
- Relationship between Helicobacter Pylori infection and metabolic syndrome components in adults.Frontiers in endocrinology · 2025Article
- Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina.European journal of medical research · 2024Article
- Comparison ofJGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress.Scientific reports · 2024Article
- The association between Helicobacter pylori infection and the risk for gout in hyperuricemia patients in China - A cross-sectional study.Gut pathogens · 2024Article
- Article
- Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis.European journal of dentistry · 2023Article
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- Role of Outer Membrane Vesicles FromFrontiers in cell and developmental biology · 2021Article
- Relationship BetweenInternational journal of general medicine · 2021Review
- Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance.International journal of molecular sciences · 2020Review
- The Role of the Microbiota in the Diabetic Peripheral Artery Disease.Mediators of inflammation · 2019Review
- H. pylori infection and extra-gastroduodenal diseases.Journal of biomedical science · 2018Review
- Article
- Cooperation of Gastric Mononuclear Phagocytes withJournal of immunology (Baltimore, Md. : 1950) · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of infection in the pathogenesis of atherosclerosis is still a matter of debate.
aimsThis study aimed to investigate the effect of CagA-positive Helicobacter pylori (H. pylori) strains infection on coronary atherosclerosis in patients with coronary heart disease and to elucidate how cytotoxin-associated gene A (CagA)-positive H. pylori strains infections were involved in coronary heart disease by examining the levels of serum lipid, high-sensitivity C-reactive protein (hsCRP) and oxidized low-density protein (oxLDL).
methodsRecruited for this study were 159 patients with coronary heart disease. The severity of coronary heart disease was estimated by calculating the Gensini score. Serum oxLDL and hsCRP were examined in all subjects. Current H. pylori infection was determined in all participants by means of a modified (13C) urea breath test (>200 dpm classified as positive). IgG antibodies against CagA protein were analyzed by enzyme immunoassays. Antibody titers against CagA (≥8 U/ml) were classified as positive. All subjects were divided into three groups, including an uninfected group (n=30), an H. pylori +CagA- group (n=69), and an H. pylori +CagA+ group (n=60).
resultsSignificant differences were found among the three groups in levels of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, serum hsCRP, oxLDL, and severity of coronary atherosclerosis (p<0.05). The levels of total cholesterol, LDL, apolipoprotein B, serum hsCRP, oxLDL were significantly elevated and the severity of coronary atherosclerosis was significantly increased in H. pylori +CagA+ group (p<0.05).
conclusionsMore serious coronary atherosclerosis was observed in CHD patients with H. pylori +CagA+ infection. H. pylori +CagA+ infection might be involved in coronary atherosclerosis by modifying serum lipids, enhancing LDL oxidation, and activating the inflammatory responses.
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