ReviewIntensive care medicine2010
The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review.
Review in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT05361252 (Restrictive Versus Liberal Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Restrictive Versus Liberal Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection: a Prospective Randomised Trial of Perioperative Quality of Care
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Retraction Note to: The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review.Intensive care medicine · 2020Article
- Blood Loss Estimation in Small Animals and Assessment of a Pictorial Tool to Improve Accuracy in a Global Population of Veterinary Anesthesia Staff.Frontiers in veterinary science · 2020Article
- Narrative reviews from a fraudulent author: reasons to retract.Intensive care medicine · 2019Article
- Observational
- Effects of Fluids on the Macro- and Microcirculations.Critical care (London, England) · 2018Review
- Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.Critical care medicine · 2016Review
- Cumulative Fluid Balance and Mortality in Septic Patients With or Without Acute Kidney Injury and Chronic Kidney Disease.Critical care medicine · 2016Observational
- Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation.Critical care (London, England) · 2015Article
- Microcirculatory dysfunction and tissue oxygenation in critical illness.Acta anaesthesiologica Scandinavica · 2015Review
- Article
- From macrohemodynamic to the microcirculation.Critical care research and practice · 2013Article
- Critical care considerations in the management of the trauma patient following initial resuscitation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Review
- Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses.Intensive care medicine · 2012Review
- The Microcirculation Is Unchanged in Neonates with Severe Respiratory Failure after the Initiation of ECMO Treatment.Critical care research and practice · 2012Article
- Year in review in Intensive Care Medicine 2010: II. Pneumonia and infections, cardiovascular and haemodynamics, organization, education, haematology, nutrition, ethics and miscellanea.Intensive care medicine · 2011Article
- Use of near-infrared spectroscopy during a vascular occlusion test to assess the microcirculatory response during fluid challenge.Critical care (London, England) · 2011Article
- Recommendations for haemodynamic and neurological monitoring in repair of acute type a aortic dissection.Anesthesiology research and practice · 2011Article
- Fluid management in patients with trauma: Restrictive versus liberal approach.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
- Retraction · 2020-05-13Author Unresponsive · Cites Retracted Work · Unreliable Results and/or Conclusions · · Joachim Boldt has institutional finding of misconduct;
- Retracted
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn optimal volume replacement strategy aims to restore systemic hemodynamics with the ultimate goals of improving organ perfusion and microcirculation for sustaining adequate tissue oxygenation. This review presents the (patho)physiological basis of hypovolemia, microcirculation, and tissue oxygenation and presents a literature review on the effects of plasma substitutes on microperfusion and oxygenation in the clinical setting.
methodsLiterature review of the effects of fluid therapy on microcirculation and tissue oxygenation using PubMed search including original papers in English from 1988 to 2009.
resultsWe identified a total of 14 articles dealing with the effects of different crystalloids and colloids on organ perfusion, microcirculation, and tissue oxygenation in patients. The results are divergent, but there is a general trend that colloids are superior to crystalloids in improving organ perfusion, microcirculation, and tissue oxygenation. Due to the limited number of studies and different study conditions, a meta-analysis on the effects of the volume replacement strategies on microcirculation is not possible.
conclusionsImproving the microcirculation by volume replacement appears to be a promising issue when treating the critically ill. The growing insights from animal experiments have to be translated into the clinical setting to identify the optimal fluid regimen for correcting hypovolemia. New techniques for monitoring microcirculation at the bedside might provide such endpoints, although these have to be validated also in the clinical setting. Whether improved microperfusion and tissue oxygenation by fluid therapy will also improve patient outcomes will have to be proven by future studies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.