ArticlePLoS pathogens2010
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Insight Into Inflammasome Signaling: Implications forFrontiers in immunology · 2020Pooled it
- Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity.PLoS biology · 2026Article
- ERK pathway reactivation prevents anthrax toxin lethality in mice.Nature microbiology · 2025Article
- Review
- Strategies of bacterial detection by inflammasomes.Cell chemical biology · 2024Review
- The NLR gene family: from discovery to present day.Nature reviews. Immunology · 2023Review
- Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics.Toxins · 2023Article
- Discovery of a rapidly evolving yeast defense factor,Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.Cell reports · 2023Article
- NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury.Frontiers in immunology · 2022Review
- Pyroptosis: A New Frontier in Kidney Diseases.Oxidative medicine and cellular longevity · 2021Review
- Progesterone SuppressesFrontiers in microbiology · 2021Article
- Activation of the CARD8 Inflammasome Requires a Disordered Region.Cell reports · 2020Article
- Molecular actions of NLR immune receptors in plants and animals.Science China. Life sciences · 2020Review
- The NLRP1 and CARD8 inflammasomes.Immunological reviews · 2020Review
- Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes.Journal of biomedical science · 2020Review
- Characterization of the NLRP1 inflammasome response in bovine species.Innate immunity · 2020Article
- Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome.Nature communications · 2020Article
- DPP8/9 inhibitors are universal activators of functional NLRP1 alleles.Cell death & disease · 2019Article
- The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.The EMBO journal · 2019Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine macrophage sensitivity and mouse strain susceptibility to toxin challenge is poor. In rats, LT induces a rapid death in as little as 37 minutes through unknown mechanisms. We used a recombinant inbred (RI) rat panel of 19 strains generated from LT-sensitive and LT-resistant progenitors to map LT sensitivity in rats to a locus on chromosome 10 that includes the inflammasome NOD-like receptor (NLR) sensor, Nlrp1. This gene is the closest rat homolog of mouse Nlrp1b, which was previously shown to control murine macrophage sensitivity to LT. An absolute correlation between in vitro macrophage sensitivity to LT-induced lysis and animal susceptibility to the toxin was found for the 19 RI strains and 12 additional rat strains. Sequencing Nlrp1 from these strains identified five polymorphic alleles. Polymorphisms within the N-terminal 100 amino acids of the Nlrp1 protein were perfectly correlated with LT sensitivity. These data suggest that toxin-mediated lethality in rats as well as macrophage sensitivity in this animal model are controlled by a single locus on chromosome 10 that is likely to be the inflammasome NLR sensor, Nlrp1.
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