ArticlePLoS computational biology2010
Chemotactic response and adaptation dynamics in Escherichia coli.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Automated Classification of Homeostasis Structure in Input-Output Networks.Bulletin of mathematical biology · 2026Article
- Analyzing an organism's sensors using Maximum Entropy (MaxEnt) models with bias, variance, and confusion matrices.PloS one · 2026Article
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Deciphering the proteome ofComputational and structural biotechnology journal · 2025Article
- Homeostasis in networks with multiple inputs.Journal of mathematical biology · 2024Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- Article
- Ras inhibitor CAPRI enables neutrophil-like cells to chemotax through a higher-concentration range of gradients.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Adaptive tuning of cell sensory diversity without changes in gene expression.Science advances · 2020Article
- Modular DNA strand-displacement controllers for directing material expansion.Nature communications · 2018Article
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Mathematical Analysis of the Escherichia coli Chemotaxis Signalling Pathway.Bulletin of mathematical biology · 2018Article
- Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET.eLife · 2017Article
- Article
- Drift and Behavior of E. coli Cells.Biophysical journal · 2017Article
- Feedback between motion and sensation provides nonlinear boost in run-and-tumble navigation.PLoS computational biology · 2017Article
- Article
- Information processing in bacteria: memory, computation, and statistical physics: a key issues review.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- Understanding the link between single cell and population scale responses of Escherichia coli in differing ligand gradients.Computational and structural biotechnology journal · 2015Article
- A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides (†).Interface focus · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is integral for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from repellents. Its biochemical mechanism based on methylation and demethylation of chemoreceptors has long been known. Despite the importance of adaptation for cell memory and behavior, the dynamics of adaptation are difficult to reconcile with current models of precise adaptation. Here, we follow time courses of signaling in response to concentration step changes of attractant using in vivo fluorescence resonance energy transfer measurements. Specifically, we use a condensed representation of adaptation time courses for efficient evaluation of different adaptation models. To quantitatively explain the data, we finally develop a dynamic model for signaling and adaptation based on the attractant flow in the experiment, signaling by cooperative receptor complexes, and multiple layers of feedback regulation for adaptation. We experimentally confirm the predicted effects of changing the enzyme-expression level and bypassing the negative feedback for demethylation. Our data analysis suggests significant imprecision in adaptation for large additions. Furthermore, our model predicts highly regulated, ultrafast adaptation in response to removal of attractant, which may be useful for fast reorientation of the cell and noise reduction in adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.