ArticleBeilstein journal of organic chemistry2010
The C-F bond as a conformational tool in organic and biological chemistry.
Article in Beilstein journal of organic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter.FEBS open bio · 2026Review
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Modified Julia Olefination Approach to Chiral α-Fluorovinyl Amino Alcohols and Amino Acids, via Fluorovinyl Oxazolidine Precursors, Conformational and Crystallographic Analyses.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Biocatalytic synthesis of alkoxylated phenazine derivatives using methyltransferases.Microbial cell factories · 2026Article
- How fluorine substituents strengthen aryl C-H bonds.Chemical science · 2026Article
- The Effect ofACS medicinal chemistry letters · 2026Article
- Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective.Journal of medicinal chemistry · 2026Review
- Structure-Tunable Fluorinated Polyester Electrolytes with Enhanced Interfacial Stability for Recyclable Solid-State Lithium Metal Batteries.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Difluorinated Cyclohexanes: Energetics and Intra- and Intermolecular Interactions.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Harnessing Fluorine Chemistry: Strategies for Per- and Polyfluoroalkyl Substances Removal and Enrichment.ChemPlusChem · 2025Review
- pEnvironmental science & technology · 2025Article
- Capturing Unstable Carbanionic Intermediates via Halogen Transfer: Base-Promoted Oxidative Coupling Reactions of α,α-Difluoromethylarenes.Angewandte Chemie (International ed. in English) · 2025Article
- Origami with small molecules: exploiting the C-F bond as a conformational tool.Beilstein journal of organic chemistry · 2025Review
- Chloroimidazolium Deoxyfluorination Reagent with HThe Journal of organic chemistry · 2024Article
- Conformational Analysis of 1,3-Difluorinated Alkanes.The Journal of organic chemistry · 2024Article
- Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral Properties.Molecules (Basel, Switzerland) · 2024Review
- Synthetic Advantages of Defluorinative C-F Bond Functionalization.Angewandte Chemie (International ed. in English) · 2023Review
- Drug Discovery Based on Fluorine-Containing Glycomimetics.Molecules (Basel, Switzerland) · 2023Review
- Tinker, Tailor, Soldier, Spy: The Diverse Roles That Fluorine Can Play within Amino Acid Side Chains.Molecules (Basel, Switzerland) · 2023Review
- Access to 2-Fluorinated Aziridine-2-phosphonates fromMolecules (Basel, Switzerland) · 2023Article
9 more citing papers are in PubMed but not listed here.
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1 author.
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Abstract
Organofluorine compounds are widely used in many different applications, ranging from pharmaceuticals and agrochemicals to advanced materials and polymers. It has been recognised for many years that fluorine substitution can confer useful molecular properties such as enhanced stability and hydrophobicity. Another impact of fluorine substitution is to influence the conformations of organic molecules. The stereoselective introduction of fluorine atoms can therefore be exploited as a conformational tool for the synthesis of shape-controlled functional molecules. This review will begin by describing some general aspects of the C-F bond and the various conformational effects associated with C-F bonds (i.e. dipole-dipole interactions, charge-dipole interactions and hyperconjugation). Examples of functional molecules that exploit these conformational effects will then be presented, drawing from a diverse range of molecules including pharmaceuticals, organocatalysts, liquid crystals and peptides.
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