ArticleThe open dentistry journal2010
The effect of age on the gingival crevicular fluid composition during experimental gingivitis. A pilot study.
Article in The open dentistry journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration.Journal of materials science. Materials in medicine · 2013Trial
- Effects of aging on host responses in gingival crevicular fluid in natural gingivitis.Frontiers in immunology · 2026Article
- Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis.Geriatrics (Basel, Switzerland) · 2023Article
- Analysis of senescence in gingival tissues and gingival fibroblast cultures.Clinical and experimental dental research · 2022Article
- High Glucose Exacerbates TNF-Stem cells international · 2020Article
- Resistance and resilience to experimental gingivitis: a systematic scoping review.BMC oral health · 2019Article
- Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses.Clinical oral implants research · 2017Article
- Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis.Journal of Istanbul University Faculty of Dentistry · 2017Article
- The Dynamics of Oxidized LDL during Atherogenesis.Journal of lipids · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytokines have been proposed as potentially useful diagnostic or prognostic markers of periodontal inflammation related alterations during the experimental gingivitis model. The role of ageing in periodontal disease needs further elucidation; therefore investigations of its influence on host response are needed.
objectiveTo study the effect of age on interleukins IL -6, IL-8 and TNF-a levels in gingival crevicular fluid (GCF) and their correlations to clinical parameters during experimental gingivitis. MATERIALS AND
methodsFive young subjects (20-22 years old) and five old subjects (61-65 years old), all periodontal healthy, participated in this clinical trial. A professional plaque control programme was undertaken to establish healthy gingival conditions at baseline. Plaque index (PI), gingival index (GI) were recorded at 60 sites at baseline, after 21 days of no oral hygiene and one week later after professional cleaning and reestablishment of oral hygiene procedures. A total of 180 samples were analyzed with ELISA for levels of IL -6, IL-8 and TNF-a in gingival crevicular fluid. The examination included the mesiobuccal sites of the Ramfjord teeth. Comparisons between and within groups were performed by non-parametric tests (Mann- Withney) and correlations were sought for with Wilcoxon test. Significance was set at p=0.05.
resultsResults showed significant diferences between the two groups with regard to the plaque and bleeding scores and GCF volume, all of which proved to be more pronounced in old group. With respect to laboratory data, mean cytokine concentrations were in general lower in young group. TNF-a had a steady increase for the adults, which was found to be statistically significant between Days 0 and 21, IL-8 showed a statistically significant decrease at Day 28 in the young group and finally IL-6 showed a fluctuation, which was totally adverse for the two groups at each time point.
conclusionWithin the limitations of the present study, age cannot be identified as a factor that strongly affects the cytokine expression and fluctuations even in a well-controlled environment of inflammation, such as experimental gingivitis.
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