ArticleEuropean journal of clinical nutrition2010
Reliability of fasting plasma alkylresorcinol concentrations measured 4 months apart.
Article in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Plasma Alkylresorcinols Is an Objective Biomarker for Gluten Intake in Young Children.The Journal of nutrition · 2025Trial
- Comparison of plasma alkylresorcinols (AR) and urinary AR metabolites as biomarkers of compliance in a short-term, whole-grain intervention study.European journal of nutrition · 2016Trial
- Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.European journal of clinical nutrition · 2014Trial
- Trial
- Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study.The American journal of clinical nutrition · 2012Trial
- Dietary biomarkers-an update on their validity and applicability in epidemiological studies.Nutrition reviews · 2024Review
- New alkylresorcinol metabolites in spot urine as biomarkers of whole grain wheat and rye intake in a Swedish middle-aged population.European journal of clinical nutrition · 2018Article
- Evaluation of alkylresorcinols in adipose tissue biopsies as a long-term biomarker of whole-grain wheat and rye intake in free-living Swedish men and women.Public health nutrition · 2018Article
- Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.Journal of the National Cancer Institute · 2014Article
- Long-term reproducibility of plasma alkylresorcinols as biomarkers of whole-grain wheat and rye intake within Northern Sweden Health and Disease Study Cohort.European journal of clinical nutrition · 2013Article
- Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults.The Journal of nutrition · 2012Article
- Reliability of fasting plasma alkylresorcinol metabolites concentrations measured 4 months apart.European journal of clinical nutrition · 2012Article
- Alkylresorcinol metabolite concentrations in spot urine samples correlated with whole grain and cereal fiber intake but showed low to modest reproducibility over one to three years in U.S. women.The Journal of nutrition · 2012Article
- Present status and perspectives on the use of alkylresorcinols as biomarkers of wholegrain wheat and rye intake.Journal of nutrition and metabolism · 2012Article
- Determinants of plasma alkylresorcinol concentration in Danish post-menopausal women.European journal of clinical nutrition · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAlkylresorcinols (ARs) have been suggested as specific dietary biomarkers of whole-grain intake. Evaluation of long-term reliability in repeatedly collected samples in population-based studies is needed to assess whether plasma AR reflect long-term exposure and may be used to study exposure-disease relationships in large-scale epidemiologic studies. The objective of this study was to analyze the reliability (reproducibility) of AR concentrations in fasting plasma measured 4 months apart. SUBJECTS/
methodsAR concentrations (C17:0, C19:0, C21:0, C23:0 and C25:0 and total ARs) were measured in fasting plasma samples from 100 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study with an interval of 4 months between blood sampling.
resultsFasting plasma AR concentrations were not significantly different between the first and second measurement over the 4-month period. Geometric means of total AR concentrations were 48.8 (95% confidence interval (CI)=41.5-57.3) nmol/l at the first and 48.7 (95% CI=41.4-57.4) nmol/l at the second measurement (P=0.99). The intraclass correlation coefficients for total AR concentrations were 0.42 (95% CI=0.25-0.57) for all, 0.55 (95% CI=0.32-0.72) for women, and 0.17 (95% CI=-0.11-0.42) for men. Comparable results were obtained for the individual homologues.
conclusionsOverall, we observed moderate reliability in concentration of total AR and individual homologues over time, although reliability was weaker in men than in women. These findings should be taken into account when using AR as blood biomarkers for whole-grain intake in large-scale epidemiologic studies.
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