Evidence map›Paper›PMID 20502328›Full record

ReviewCurrent opinion in nephrology and hypertension2010

The renin phenotype: roles and regulation in the kidney.

Maria L S Sequeira Lopez, R Ariel Gomez

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in nephrology and hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Sox6 as a new modulator of renin expression in the kidney.American journal of physiology. Renal physiology · 2020
    Article
  5. Article
  6. COX-2-derived PGEPflugers Archiv : European journal of physiology · 2018
    Article
  7. Interference with GsJournal of the American Society of Nephrology : JASN · 2017
    Article
  8. Article
  9. Pericytes synthesize renin.World journal of nephrology · 2013
    Article
  10. Article
  11. Genes that confer the identity of the renin cell.Journal of the American Society of Nephrology : JASN · 2011
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria L S Sequeira LopezDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
R Ariel Gomez
University of Virginia · US

Funding

Renin Cell Fate in the Kidney VasculatureR37HL066242 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2007 to 2016
$4.0M
RENIN CELL FATE IN THE KIDNEY VASCULATURER01HL066242 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GOMEZ, ROBERTO ARIEL · 2001 to 2005
$1.7M
Development of the renin-expressing cellK08DK075481 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2006 to 2010
$678k
NHLBI NIH HHS HL066242NHLBI NIH HHS R01 HL066242NHLBI NIH HHS R37 HL066242NIDDK NIH HHS DK75481NIDDK NIH HHS K08 DK075481
6 · The paper itself

Abstract

purpose of reviewRenin cells are fundamental for the control of blood pressure, fluid electrolyte homeostasis and kidney development. This review discusses recent discoveries regarding the mechanisms that control the identity and fate of renin cells and their role in the maintenance of kidney architecture and function. RECENT

findingsIt is now established that cyclic AMP is a crucial factor for the regulation of the renin phenotype. Furthermore, additional factors such as microRNAs and gap junctions have recently emerged as key regulators for the maintenance and proper functioning of renin cells. SUMMARY: Experiments described in this review will hopefully raise new questions regarding the mechanisms that control the identity, plasticity and function of renin cells.

Indexed as

AnimalsConnexinsGap JunctionsHumansKidneyMicroRNAsPhenotypeReninTranscription FactorsConnexinsMicroRNAsReninTranscription Factors

Identifiers

PMID20502328
PMCPMC3079389
OpenAlexW2081428802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.