Trial reportObstetrics and gynecology2010
Chlorhexidine vaginal and infant wipes to reduce perinatal mortality and morbidity: a randomized controlled trial.
Trial report in Obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438110 (Project to Understand & Research Preterm Pregnancy Outcomes-South Asia), which is not on this map. Cited by 13 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project to Understand & Research Preterm Pregnancy Outcomes-South Asia (PURPOSe)
Who cites it
13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Which intervention design factors influence performance of community health workers in low- and middle-income countries? A systematic review.Health policy and planning · 2015Pooled it
- Chlorhexidine skin or cord care for prevention of mortality and infections in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection.The Cochrane database of systematic reviews · 2014Pooled it
- Vaginal chlorhexidine during labour for preventing maternal and neonatal infections (excluding Group B Streptococcal and HIV).The Cochrane database of systematic reviews · 2014Pooled it
- Umbilical cord antiseptics for preventing sepsis and death among newborns.The Cochrane database of systematic reviews · 2013Pooled it
- Clean birth and postnatal care practices to reduce neonatal deaths from sepsis and tetanus: a systematic review and Delphi estimation of mortality effect.BMC public health · 2011Pooled it
- Application of 4% chlorhexidine to the umbilical cord stump of newborn infants in lower income countries: a systematic review and meta-analysis.Maternal health, neonatology and perinatology · 2019Review
- Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review.World journal of clinical pediatrics · 2016Review
- A New Look at Care in Pregnancy: Simple, Effective Interventions for Neglected Populations.PloS one · 2016Review
- How does context influence performance of community health workers in low- and middle-income countries? Evidence from the literature.Health research policy and systems · 2015Article
- A review of studies with chlorhexidine applied directly to the umbilical cord.American journal of perinatology · 2013Review
- Reducing neonatal infections in south and south central Vietnam: the views of healthcare providers.BMC pediatrics · 2013Article
- Serious and life-threatening pregnancy-related infections: opportunities to reduce the global burden.PLoS medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate the effects of chlorhexidine vaginal and baby wipes on fetal and neonatal mortality, respectively, and infection-related morbidity.
methodsWe performed a placebo-controlled, randomized trial of chlorhexidine vaginal and neonatal wipes to reduce neonatal sepsis and mortality in three hospitals in Pakistan. The primary study outcome was a composite of neonatal sepsis or 7-day perinatal mortality.
resultsFrom 2005 to 2008, 5,008 laboring women and their neonates were randomly assigned to receive either chlorhexidine wipes (n=2,505) or wipes with a saline placebo (n=2,503). The primary outcome was similar in the chlorhexidine and control groups (3.1% compared with 3.4%; relative risk 0.91, 95% confidence interval 0.67-1.24) as was the composite rate of neonatal sepsis or 28-day perinatal mortality (3.8% compared with 3.9%, relative risk 0.96, 95% confidence interval 0.73-1.27). At day 7, the chlorhexidine group had a lower rate of neonatal skin infection (3.3% compared with 8.2%, P<.001). With the exception of less frequent 7-day hospitalization in the chlorhexidine group, there were no significant differences in maternal outcomes between the groups.
conclusionUsing maternal chlorhexidine vaginal wipes during labor and neonatal chlorhexidine wipes does not reduce maternal and perinatal mortality or neonatal sepsis. The finding of reduced superficial skin infections on day 7 without change in sepsis or mortality suggests that this difference, although statistically significant, may not be of major importance. LEVEL OF EVIDENCE: I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.