Evidence map›Paper›PMID 20502115›Full record

ArticleAnesthesiology2010

Prognostic implications of asymptomatic left ventricular dysfunction in patients undergoing vascular surgery.

Willem-Jan Flu, Jan-Peter van Kuijk, Sanne E Hoeks, Ruud Kuiper, Olaf Schouten, Dustin Goei, Abdou Elhendy, Hence J M Verhagen, Ian R Thomson, Jeroen J Bax and 2 more

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Anesthesiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04836702 (Vascular Surgery Outcomes), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04836702 completednot on this mapstarted 2011, after this paper: background citation

Vascular Surgery Outcomes: Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients

TypeobservationalSponsorUniversity of VirginiaRan2011 to 2022Enrolled813ConditionsLeft-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Willem-Jan FluDepartment of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jan-Peter van Kuijk
Sanne E Hoeks
Ruud Kuiper
Olaf Schouten
Dustin Goei
Abdou Elhendy
Hence J M Verhagen
Ian R Thomson
Jeroen J Bax
Lee A Fleisher
Don Poldermans
Erasmus MC · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic value of heart failure symptoms on postoperative outcome is well acknowledged in perioperative guidelines. The prognostic value of asymptomatic left ventricular (LV) dysfunction remains unknown. This study evaluated the prognostic implications of asymptomatic LV dysfunction in vascular surgery patients assessed with routine echocardiography.

methodsEchocardiography was performed preoperatively in 1,005 consecutive vascular surgery patients. Systolic LV dysfunction was defined as LV ejection fraction less than 50%. Ratio of mitral-peak velocity during early and late filling, pulmonary vein flow, and deceleration time was used to diagnose diastolic LV dysfunction. Troponin-T measurements and electrocardiograms were performed routinely perioperatively. Multivariate regression analyses evaluated the relation between LV function and the study endpoints, 30-day cardiovascular events, and long-term cardiovascular mortality.

resultsLeft ventricular dysfunction was diagnosed in 506 (50%) patients of which 80% were asymptomatic. In open vascular surgery (n = 649), both asymptomatic systolic and isolated diastolic LV dysfunctions were associated with 30-day cardiovascular events (odds ratios 2.3, 95% confidence interval [CI] 1.4-3.6 and 1.8, 95% CI 1.1-2.9, respectively) and long-term cardiovascular mortality (hazard ratios 4.6, 95% CI 2.4-8.5 and 3.0, 95% CI 1.5-6.0, respectively). In endovascular surgery (n = 356), only symptomatic heart failure was associated with 30-day cardiovascular events (odds ratio 1.8, 95% CI 1.1-2.9) and long-term cardiovascular mortality (hazard ratio 10.3, 95% CI 5.4-19.3).

conclusionsThis study demonstrated that asymptomatic LV dysfunction is predictive for 30-day and long-term cardiovascular outcome in open vascular surgery patients. These data suggest that preoperative risk stratification should include not only solely heart failure symptoms but also routine preoperative echocardiography to risk stratify open vascular surgery patients.

Indexed as

AgedAged, 80 and overCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsPrognosisProspective StudiesRadiographyTroponin TVascular Surgical ProceduresVentricular Dysfunction, LeftTroponin T

Identifiers

PMID20502115
OpenAlexW2109857015

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.