ArticleJournal of child neurology2010
Cardiac and pulmonary function variability in Duchenne/Becker muscular dystrophy: an initial report.
Article in Journal of child neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- The effect of modification of DNA interference on myostatin gene expression in mice.Journal of genetics · 2024Article
- Natural History of Histopathologic Changes in Cardiomyopathy of Golden Retriever Muscular Dystrophy.Frontiers in veterinary science · 2021Article
- DMD carrier model with mosaic dystrophin expression in the heart reveals complex vulnerability to myocardial injury.Human molecular genetics · 2020Article
- Left ventricular dysfunction in Duchenne muscular dystrophy.Cardiology in the young · 2020Article
- Precision Medicine and Exercise Therapy in Duchenne Muscular Dystrophy.Sports (Basel, Switzerland) · 2019Article
- Dystrophin genotype-cardiac phenotype correlations in Duchenne and Becker muscular dystrophies using cardiac magnetic resonance imaging.The American journal of cardiology · 2015Article
- Early right ventricular fibrosis and reduction in biventricular cardiac reserve in the dystrophin-deficient mdx heart.American journal of physiology. Heart and circulatory physiology · 2015Article
- Left ventricular dysfunction in duchenne muscular dystrophy and genotype.The American journal of cardiology · 2014Article
- Sibling concordance for clinical features of Duchenne and Becker muscular dystrophies.Muscle & nerve · 2014Article
- Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Modifiers of heart and muscle function: where genetics meets physiology.Experimental physiology · 2014Review
- Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy.Herz · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The Duchenne and Becker forms of muscular dystrophy are associated with dilated cardiomyopathy and are diseases in which pulmonary function peaks and then progressively declines. In this report, the authors quantify cardiopulmonary function variability among brothers. Brothers in 3 of 7 eligible sibships had discordant pulmonary function, with significant differences between the brothers' peak forced vital capacities and their vital capacities at last comparable age. There was no relationship between pulmonary and cardiac function among the siblings. The authors concluded that despite identical genetic mutations, cardiac and pulmonary function variability was common among brothers in their clinic with Duchenne or Becker muscular dystrophy. If confirmed by larger studies, these results have negative implications for the use of genetic testing to predict cardiopulmonary course and response to therapies in Duchenne or Becker muscular dystrophy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.