ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Systemic adiponectin levels in colorectal cancer and adenoma: a systematic review and meta-analysis.International journal of obesity (2005) · 2023Pooled it
- Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies.Molecular nutrition & food research · 2015Trial
- Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer.Scientific reports · 2024Article
- Insulinemic potential of diet and risk of total and subtypes of breast cancer among US females.The American journal of clinical nutrition · 2022Article
- Type 2 diabetes and the risk of colorectal polyps: A retrospective nationwide population-based study.Medicine · 2021Observational
- Risk Factors for Recurrent Colorectal Polyps.Gut and liver · 2020Review
- The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro.Molecules (Basel, Switzerland) · 2018Review
- Epidemiology and biology of physical activity and cancer recurrence.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- A prospective evaluation of C-peptide levels and colorectal adenoma incidence.Cancer epidemiology · 2015Article
- Body mass index and colon cancer screening: the road ahead.World journal of gastroenterology · 2015Review
- Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review.World journal of gastroenterology · 2015Review
- Associations between S-adenosylmethionine, S-adenosylhomocysteine, and colorectal adenoma risk are modified by sex.American journal of cancer research · 2015Article
- Association of insulin-related serum factors with colorectal polyp number and type in adult males.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study.PloS one · 2014Article
- Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort.The American journal of clinical nutrition · 2013Article
- A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women.Cancer causes & control : CCC · 2012Article
- Adiposity factors are not related to the presence of colorectal adenomas.Clinical and experimental gastroenterology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSerum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer.
aimsTo determine whether serum adiponectin, leptin, C-peptide, and homocysteine are associated with fat, fiber, fruit and vegetable, flavonol, or dry bean intake and colorectal adenoma recurrence.
methodsUsing logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (95% CI) for adenoma recurrence in 627 participants from the control arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence.
resultsSerum concentrations of C-peptide and homocysteine were inversely related to fiber, fruit and vegetable, and flavonol intake and positively related to percentage of calories from fat (all P(trend) < or = 0.01). High homocysteine concentrations were associated with any (4th versus 1st quartile: OR, 2.26; 95% CI, 1.30-3.94) and more than one adenoma recurrence (OR, 2.11; 95% CI, 1.01-4.40). Individuals in the highest, versus lowest, tertile of serum leptin concentration had a decreased risk of advanced adenoma recurrence (OR, 0.22; 95% CI, 0.06-0.79).
conclusionOur results suggest that serum homocysteine may serve as an indicator of dietary exposure, including a low-fat and high-fiber, high-fruit and vegetable, and high-flavonol diet, as well as colorectal adenoma recurrence. IMPACT: Discovering biomarkers that are both modifiable and can predict cancer risk is critical. We identified serum homocysteine as a novel indicator that is modified by diet and predicts risk of adenoma recurrence.
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