ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Risk factors for ductal, lobular, and mixed ductal-lobular breast cancer in a screening population.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Mammographic density and risk of breast cancer by age and tumor characteristics.Breast cancer research : BCR · 2013Pooled it
- Invasive lobular carcinoma with metastasis to the pectoralis muscle.Radiology case reports · 2025Article
- A Multi-Layer Breast Cancer Model to Study the Synergistic Effect of Photochemotherapy.Micromachines · 2023Article
- Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use.European journal of nutrition · 2022Observational
- Correlation of Breast Density Grade on Mammogram With Diagnosed Breast Cancer: A Retrospective Cross-Sectional Study.Cureus · 2022Article
- Multivariate analysis of independent roles of socioeconomic status, occupational physical activity, reproductive factors, and postmenopausal hormonal therapy in risk of breast cancer.Breast cancer research and treatment · 2022Article
- Survival Outcomes in Invasive Lobular Carcinoma Compared to Oestrogen Receptor-Positive Invasive Ductal Carcinoma.Cancers · 2021Article
- Article
- Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Review
- Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas.Cancer causes & control : CCC · 2019Article
- Mammographic density parameters and breast cancer tumor characteristics among postmenopausal women.Breast cancer (Dove Medical Press) · 2019Article
- Role of DCE-MR in predicting breast cancer subtypes.La Radiologia medica · 2018Article
- E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.Scientific reports · 2018Article
- Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.Cancer causes & control : CCC · 2018Article
- Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes.Breast cancer research and treatment · 2017Article
- Is there an association between invasive lobular carcinoma of the breast and a family history of gastric cancer?Familial cancer · 2016Article
- Postmenopausal mammographic breast density and subsequent breast cancer risk according to selected tissue markers.British journal of cancer · 2015Article
- Lobular breast cancer: incidence and genetic and non-genetic risk factors.Breast cancer research : BCR · 2015Review
- Breast cancer risk in older women: results from the NIH-AARP Diet and Health Study.Cancer causes & control : CCC · 2014Article
- Impact of body mass index on prognostically relevant breast cancer tumor characteristics.Breast care (Basel, Switzerland) · 2013Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBiological distinctions between histologic subtypes of breast cancer suggest etiologic differences, although few studies have been powered to examine such differences. We compared associations between several factors and risk of ductal, lobular, and mixed ductal-lobular breast cancers.
methodsWe used risk factor data from the Breast Cancer Surveillance Consortium for 3,331,744 mammograms on 1,211,238 women, including 19,119 women diagnosed with invasive breast cancer following mammography (n = 14,818 ductal, 1,602 lobular, and 1,601 mixed ductal-lobular). Histologic subtype-specific risk factor associations were evaluated using Cox regression.
resultsSignificant positive associations with family history and breast density were similar across subtypes. Hormone therapy use was associated with increased risk of all subtypes, but was most strongly associated with lobular cancer [hazard ratio (HR) = 1.46; 95% confidence interval (CI), 1.25-1.70]. Relative to nulliparous women, parous women had lower risk of ductal and mixed but not lobular cancers (HR = 0.80; 95% CI, 0.76-0.84; HR = 0.79; 95% CI, 0.68-0.93; HR = 0.96; 95% CI, 0.81-1.15, respectively). Late age at first birth was associated with increased risk of all subtypes.
conclusionsSimilarities in risk factor associations with ductal, lobular, and mixed breast cancer subtypes were more pronounced than differences. Distinctions between subtype-specific associations were limited to analyses of hormone therapy use and reproductive history. IMPACT: The results of this study indicate that the strongest risk factors for breast cancer overall (that is, family history and breast density) are not histologic subtype specific. Additional studies are needed to better characterize subtype-specific associations with genetic, hormonal, and nonhormonal factors.
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