ArticleJournal of cell science2010
Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.PLoS neglected tropical diseases · 2026Article
- Artificial selection for resistance to copper and off-target physiological and behavioral effects in Drosophila melanogaster.Ecotoxicology and environmental safety · 2026Article
- Artificial selection for resistance to copper and off-target physiological and behavioral effects inbioRxiv : the preprint server for biology · 2025Article
- Differential effect of ubiquitous and germline depletion of Integrator complex function on C. elegans physiology.Biology open · 2025Article
- A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.Aging cell · 2025Article
- Nucleolar stress induces nucleolar stress body formation via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans.Nature communications · 2024Article
- Chemical Genetics inACS chemical biology · 2024Article
- Copper Homeostasis in the Model OrganismCells · 2024Review
- CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans.Aging cell · 2023Article
- N-acetylcysteine restores the cadmium toxicity of Caenorhabditis elegans.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Gel-free genotyping of deletion alleles inmicroPublication biology · 2020Article
- Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.PLoS genetics · 2019Article
- RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress.BMC biology · 2019Article
- PMK-1 p38 MAPK promotes cadmium stress resistance, the expression of SKN-1/Nrf and DAF-16 target genes, and protein biosynthesis in Caenorhabditis elegans.Molecular genetics and genomics : MGG · 2017Article
- Heavy Metal Stress Assay ofBio-protocol · 2017Article
- Transcriptome analysis reveals molecular anthelmintic effects of procyanidins in C. elegans.PloS one · 2017Article
- Article
- Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans.PloS one · 2014Article
- Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model.Toxicology letters · 2012Article
- Longevity and stress in Caenorhabditis elegans.Aging · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To define the mechanisms involved in the molecular response to the carcinogenic metal cadmium, two novel metal-inducible genes from C. elegans were characterized: numr-1 and numr-2 (nuclear localized metal responsive). numr-1 and numr-2 sequences and cellular patterns of expression are identical, indicating that these are functionally equivalent genes. Constitutive transcription of numr-1 and numr-2 is developmentally regulated and occurs in the intestine, in head and tail neurons, and vulva muscles. Exposure to metals induces numr-1 and numr-2 transcription in pharyngeal and intestinal cells. Other environmental stressors do not affect transcription, indicating that these are metal-specific, stress-responsive genes. NUMR-1 and NUMR-2 target to nuclei and colocalize with HSF-1, suggesting that they may be components of nuclear stress granules. Nematodes overexpressing NUMR-1 and NUMR-2 are resistant to stress and live longer than control animals; likewise reducing expression increases sensitivity to metals and decreases neuromuscular functions. Upstream regulatory regions of both genes contain potential binding sites for DAF-16 and SKN-1, which are components of the insulin-IGF-like signaling pathway. This pathway regulates longevity and stress responses in C. elegans. NUMR-1 and NUMR-2 may function to promote resistance to environmental stressors and longevity, which is mediated by the insulin-IGF-like signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.