Evidence map›Paper›PMID 20501640›Full record

ArticleMolecular endocrinology (Baltimore, Md.)2010

Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function.

Aritro Sen, Stephen R Hammes

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular endocrinology (Baltimore, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03378713 (Clinical Effect of Follicular Preparation With Testosterone in Poor Ovarian Response), which is not on this map. Cited by 134 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 5 pooled it
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03378713 phase3completednot on this mapstarted 2017, after this paper: background citation

Clinical Effect of Follicular Preparation With Testosterone in Poor Ovarian Response: a Randomized Controlled Clinical Trial (TESTOPRIM)

TypeinterventionalSponsorInstituto de Investigacion Sanitaria La FeRan2017 to 2019Enrolled63ConditionsInfertility, FemaleArmsGROUP 1: Long testosterone, GROUP 2: Short testosterone, GROUP 3: Control
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 5 syntheses or guidelines pooled it, 309 citations in OpenAlex.

  1. Pooled it
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  12. Article
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  15. Ovarian stimulation by promoting basal follicular growth.Reproductive biology and endocrinology : RB&E · 2025
    Review
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aritro SenDivision of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Stephen R Hammes
University of Rochester Medical Center · US

Funding

Nongenomic Steroid Signaling in OocytesR01DK059913 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HAMMES, STEPHEN R. · 2002 to 2009
$2.8M
NIDDK NIH HHS DK59913NIDDK NIH HHS R01 DK059913
6 · The paper itself

Abstract

The physiological significance of androgens in female reproduction was unclear until female mice with global knockout of androgen receptor (AR) expression were found to have reduced fertility with abnormal ovarian function. However, because ARs are expressed in a myriad of reproductive tissues, including the hypothalamus, pituitary, and various ovarian cells, the role of tissue-specific ARs in regulating female fertility remained unknown. To examine the importance of ovarian ARs in female reproduction, we generated granulosa cell (GC)- and oocyte-specific AR-knockout (ARKO) mice by crossing AR-flox mice with MisRIIcre (GC-specific) or growth differentiation factor growth differentiation factor-9cre (oocyte-specific) mice. Relative to heterozygous and wild-type mice, GC-specific ARKO mice had premature ovarian failure and were subfertile, with longer estrous cycles and fewer ovulated oocytes. In addition, ovaries from GC-specific knockout mice contained more preantral and atretic follicles, with fewer antral follicles and corpus lutea. Finally, in vitro growth of follicles from GC-specific AR-null mice was slower than follicles from wild-type animals. In contrast to GC-specific AR-null mice, fertility, estrous cycles, and ovarian morphology of oocyte-specific ARKO mice were normal, although androgens no longer promoted oocyte maturation in these animals. Together, our data indicate that nearly all reproductive phenotypes observed in global ARKO mice can be explained by the lack of AR expression in GCs. These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility.

Indexed as

AnimalsBlotting, WesternEstrous CycleFemaleFertilityFollicular AtresiaGranulosa CellsImmunohistochemistryIn Situ Nick-End LabelingMiceMice, KnockoutOocytesOvaryPolymerase Chain ReactionPrimary Ovarian InsufficiencyReceptors, AndrogenReceptors, Androgen

Identifiers

PMID20501640
PMCPMC2903904
OpenAlexW2042378785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.