ArticleNucleic acids research2010
GSA-SNP: a general approach for gene set analysis of polymorphisms.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 7 of them syntheses that pooled it.
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Who cites it
92 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.Scientific reports · 2016Pooled it
- Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2015Pooled it
- Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.Human molecular genetics · 2014Pooled it
- Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.PLoS genetics · 2014Pooled it
- Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.Brain imaging and behavior · 2014Pooled it
- Pooled it
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.Nature genetics · 2011Pooled it
- Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.Circulation. Cardiovascular genetics · 2015Trial
- Human genome-guided identification of memory-modulating drugs.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- A review of post-GWAS studies in schizophrenia.Translational psychiatry · 2025Review
- Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population.Frontiers in aging neuroscience · 2023Article
- Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.Acta neuropathologica communications · 2021Article
- Models of the Gene Must Inform Data-Mining Strategies in Genomics.Entropy (Basel, Switzerland) · 2020Review
- Review
- Regional imaging genetic enrichment analysis.Bioinformatics (Oxford, England) · 2020Article
- Fifteen Years of Gene Set Analysis for High-Throughput Genomic Data: A Review of Statistical Approaches and Future Challenges.Entropy (Basel, Switzerland) · 2020Review
- Bioinformatics services for analyzing massive genomic datasets.Genomics & informatics · 2020Article
- Article
- Brain Imaging Genomics: Integrated Analysis and Machine Learning.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020Article
- Gene-set association and epistatic analyses reveal complex gene interaction networks affecting flowering time in a worldwide barley collection.Journal of experimental botany · 2019Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association (GWA) study aims to identify the genetic factors associated with the traits of interest. However, the power of GWA analysis has been seriously limited by the enormous number of markers tested. Recently, the gene set analysis (GSA) methods were introduced to GWA studies to address the association of gene sets that share common biological functions. GSA considerably increased the power of association analysis and successfully identified coordinated association patterns of gene sets. There have been several approaches in this direction with some limitations. Here, we present a general approach for GSA in GWA analysis and a stand-alone software GSA-SNP that implements three widely used GSA methods. GSA-SNP provides a fast computation and an easy-to-use interface. The software and test datasets are freely available at http://gsa.muldas.org. We provide an exemplary analysis on adult heights in a Korean population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.