ArticleEuropean journal of endocrinology2010
Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity.
Article in European journal of endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03610412 (Effect of Cinnamomum Cassia as an Enhancer of the Insulin Response of the Insulin-Like Growth Factor-1 and Metabolic Control in Patients With Type 2 Diabetes Mellitus Treated With Metformin Without Glycemic Control), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Cinnamomum Cassia as an Enhancer of the Insulin Response of the Insulin-Like Growth Factor-1 and Metabolic Control in Patients With Type 2 Diabetes Mellitus Treated With Metformin Without Glycemic Control
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta-analysis.The International journal of eating disorders · 2019Pooled it
- Eight Days of Water-Only Fasting Promotes Favorable Changes in the Functioning of the Urogenital System of Middle-Aged Healthy Men.Nutrients · 2020Trial
- Caloric restriction as a possible pitfall for persistent acromegaly follow-up - case report.BMC endocrine disorders · 2023Article
- In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Reference values for IGF-I serum concentration in an adult population: use of the VARIETE cohort for two new immunoassays.Endocrine connections · 2021Article
- Role of Obesity in the Tumorigenesis of Gastric Cancer.International journal of preventive medicine · 2020Review
- Updates in Diagnosis and Treatment of Acromegaly.European endocrinology · 2018Review
- Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children.Calcified tissue international · 2017Review
- Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women.Calcified tissue international · 2017Review
- Review
- Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects.PloS one · 2016Article
- Chemopreventive potential of green tea catechins in hepatocellular carcinoma.International journal of molecular sciences · 2015Review
- Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18-65 years old) who are overfat, or obese; systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2015Article
- Immunologic and mass-spectrometric estimates of SHBG concentrations in healthy women.Metabolism: clinical and experimental · 2014Article
- Determinants of GH resistance in malnutrition.The Journal of endocrinology · 2014Review
- Mechanisms of obesity-induced gastrointestinal neoplasia.Gastroenterology · 2014Review
- Ghrelin: central and peripheral implications in anorexia nervosa.Frontiers in endocrinology · 2013Article
- An overview of the contribution of fatness and fitness factors, and the role of exercise, in the formation of health status for individuals who are overweight.Journal of diabetes and metabolic disorders · 2012Article
- Body composition and skeletal health: too heavy? Too thin?Current osteoporosis reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
contextChronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal.
objectiveTo investigate the determinants of IGF1 and GH across the weight spectrum in women.
designCross-sectional study.
settingClinical research center. STUDY
participantsIn total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age.
interventionNone.
main outcome measuresPooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E(2)), testosterone, SHBG, insulin, free fatty acids, and trunk fat.
resultsFree testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E(2) (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded.
conclusionsFree testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.