Evidence map›Paper›PMID 20501551›Full record

ArticleBioinformatics (Oxford, England)2010

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

George Khelashvili, Kevin Dorff, Jufang Shan, Marta Camacho-Artacho, Lucy Skrabanek, Bas Vroling, Michel Bouvier, Lakshmi A Devi, Susan R George, Jonathan A Javitch and 9 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Interface Prediction for GPCR Oligomerization Between Transmembrane Helices.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. The GPCR heterotetramer: challenging classical pharmacology.Trends in pharmacological sciences · 2015
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

George KhelashviliDepartment of Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY, USA.
Kevin Dorff
Jufang Shan
Marta Camacho-Artacho
Lucy Skrabanek
Bas Vroling
Michel Bouvier
Lakshmi A Devi
Susan R George
Jonathan A Javitch
Martin J Lohse
Graeme Milligan
Richard R Neubig
Krzysztof Palczewski
Marc Parmentier
Jean-Philippe Pin
Gerrit Vriend
Fabien Campagne
Marta Filizola

Funding

Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
RECEPTORS MEDIATING DRUG DEPENDENCER01DA007223 · NIDA · UNIVERSITY OF TORONTO · PI GEORGE, SUSAN R · 1991 to 2013
$2.5M
INFORMATICS OF GPCR DIMERS IN DRUG ABUSE MECHANISMSR21DA017976 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI FILIZOLA, MARTA · 2005 to 2009
$1.3M
Molecular Determinants for the Action of PsychostimulantsK05DA022413 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2007 to 2016
$1.3M
NIDA NIH HHS DA017976NIDA NIH HHS K05 DA022413NIDA NIH HHS R01 DA007223NIDA NIH HHS R21 DA017976NIMH NIH HHS R01 MH054137
6 · The paper itself

Abstract

summaryRapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers. AVAILABILITY AND IMPLEMENTATION: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org

Indexed as

SoftwareDatabases, FactualInternetKnowledge BasesReceptors, G-Protein-CoupledReceptors, G-Protein-Coupled

Identifiers

PMID20501551
PMCPMC2894509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.