ArticleThe EMBO journal1991
A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 175 citations in OpenAlex.
- Gene regulatory network determinants of rapid recall in human memory CD4Cell reports · 2026Article
- Scoring Systems for Immunohistochemistry in Urothelial Carcinoma.Methods in molecular biology (Clifton, N.J.) · 2023Article
- GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Molecular and cellular biology · 2017Article
- Characterization of kiss2 and kissr2 genes and the regulation of kisspeptin on the HPG axis in Cynoglossus semilaevis.Fish physiology and biochemistry · 2017Article
- The GATA factor revolution in hematology.Blood · 2017Review
- Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness.F1000Research · 2015Article
- Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression.Biomedical reports · 2014Article
- Establishment of a cell-type-specific genetic network by the mediator complex component Med1.Molecular and cellular biology · 2013Article
- Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALB/C Mice by Inhibiting Th2 Signal.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.Nucleic acids research · 2012Review
- HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.Clinical & developmental immunology · 2012Review
- In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.Cancer immunology, immunotherapy : CII · 2011Article
- From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Immunological reviews · 2010Review
- Transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase by interacting with Sp1 and AP4.Neurochemical research · 2008Article
- Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach.Journal of carcinogenesis · 2008Article
- Genome structure and thymic expression of an endogenous retrovirus in zebrafish.Journal of virology · 2004Article
- Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.Journal of clinical immunology · 2003Review
- Structure and specificity of GATA proteins in Th2 development.Molecular and cellular biology · 2001Article
- Molecular regulation of cytokine gene expression during the immune response.Journal of clinical immunology · 1999Review
- A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human GATA1, hGATA1 (previously called NF-E1, GF-1 or Eryf-1), a major sequence-specific DNA-binding protein of the erythrocytic lineage, is a member of a zinc-finger family of DNA-binding proteins. We report here the cloning of a human cDNA for a new member of this family. This member, called hGATA3, has 85% amino acid homology with hGATA1 in the DNA-binding domain and no homology elsewhere in the protein. Unlike hGATA1, hGATA3 is not localized on the X chromosome and we map it to the 10p15 band of the human genome. Northern blot analysis indicates that this factor is a T-cell specific transcription factor, present before activation and up-regulated during T-cell activation. The encoded hGATA3 protein, made in an in vitro transcription-translation assay, binds the WGATAR motif present in the human T-cell receptor (TCR) delta gene enhancer and, by transfection in HeLa cells, we show that hGATA3 can transactivate this TCR delta gene enhancer. Interestingly this enhancer binds and is also transactivated by hGATA1. Conversely, the promoter of the human glycophorin B (GPB), which is erythroid-specific and contains two WGATAR motifs, binds and is transactivated by hGATA1 and, to a lesser extent, by hGATA3. These results indicate that the activation of specific genes by hGATA1 or hGATA3 is partly governed by the lineage expression of these two factors during haematopoiesis and that, in the T-cell lineage, hGATA3 binds the human TCR delta gene enhancer and is involved in its expression.
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