ArticleBMC veterinary research2010
A genomics-informed, SNP association study reveals FBLN1 and FABP4 as contributing to resistance to fleece rot in Australian Merino sheep.
Article in BMC veterinary research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Deciphering the cellular landscape and genetic underpinnings of fiber diameter determined by dermal papilla cells in fine-wool sheep.Frontiers in cell and developmental biology · 2026Article
- Ovine Toll-like Receptor 9 (Animals : an open access journal from MDPI · 2021Article
- OvineFrontiers in genetics · 2021Article
- Identification of Regulatory Functions of LncRNAs Associated WithFrontiers in genetics · 2021Article
- Discovery of genes and proteins possibly regulating mean wool fibre diameter using cDNA microarray and proteomic approaches.Scientific reports · 2020Article
- Single-nucleotide polymorphism-based genetic diversity analysis of the Kilakarsal and Vembur sheep breeds.Veterinary world · 2017Article
- Identification of skin-expressed genes possibly associated with wool growth regulation of Aohan fine wool sheep.BMC genetics · 2014Article
- Differential expression of genes and proteins associated with wool follicle cycling.Molecular biology reports · 2014Article
- Article
- Allelic variation in ovine fatty acid-binding protein (FABP4) gene.Molecular biology reports · 2012Article
- miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFleece rot (FR) and body-strike of Merino sheep by the sheep blowfly Lucilia cuprina are major problems for the Australian wool industry, causing significant losses as a result of increased management costs coupled with reduced wool productivity and quality. In addition to direct effects on fleece quality, fleece rot is a major predisposing factor to blowfly strike on the body of sheep. In order to investigate the genetic drivers of resistance to fleece rot, we constructed a combined ovine-bovine cDNA microarray of almost 12,000 probes including 6,125 skin expressed sequence tags and 5,760 anonymous clones obtained from skin subtracted libraries derived from fleece rot resistant and susceptible animals. This microarray platform was used to profile the gene expression changes between skin samples of six resistant and six susceptible animals taken immediately before, during and after FR induction. Mixed-model equations were employed to normalize the data and 155 genes were found to be differentially expressed (DE). Ten DE genes were selected for validation using real-time PCR on independent skin samples. The genomic regions of a further 5 DE genes were surveyed to identify single nucleotide polymorphisms (SNP) that were genotyped across three populations for their associations with fleece rot resistance.
resultsThe majority of the DE genes originated from the fleece rot subtracted libraries and over-representing gene ontology terms included defense response to bacterium and epidermis development, indicating a role of these processes in modulating the sheep's response to fleece rot. We focused on genes that contribute to the physical barrier function of skin, including keratins, collagens, fibulin and lipid proteins, to identify SNPs that were associated to fleece rot scores.
conclusionsWe identified FBLN1 (fibulin) and FABP4 (fatty acid binding protein 4) as key factors in sheep's resistance to fleece rot. Validation of these markers in other populations could lead to vital tests for marker assisted selection that will ultimately increase the natural fleece rot resistance of Merino sheep.
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