ArticleBMC evolutionary biology2010
Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Bi-alignments with affine gaps costs.Algorithms for molecular biology : AMB · 2022Article
- The evolution of hemocyanin genes in Tectipleura: a multitude of conserved introns in highly diverse gastropods.BMC ecology and evolution · 2021Article
- Is there any intron sliding in mammals?BMC evolutionary biology · 2020Article
- A mechanism for a single nucleotide intron shift.Nucleic acids research · 2017Article
- Plant Actin-Depolymerizing Factors Possess Opposing Biochemical Properties Arising from Key Amino Acid Changes throughout Evolution.The Plant cell · 2017Article
- Splice Sites Seldom Slide: Intron Evolution in Oomycetes.Genome biology and evolution · 2016Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Mechanisms of intron gain and loss in Drosophila.BMC evolutionary biology · 2011Article
- Characterization of maltase clusters in the genus Drosophila.Journal of molecular evolution · 2011Article
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Abstract
backgroundPositions of spliceosomal introns are often conserved between remotely related genes. Introns that reside in non-conserved positions are either novel or remnants of frequent losses of introns in some evolutionary lineages. A recent gain of such introns is difficult to prove. However, introns verified as novel are needed to evaluate contemporary processes of intron gain.
resultsWe identified 25 unambiguous cases of novel intron positions in 31 Drosophila genes that exhibit near intron pairs (NIPs). Here, a NIP consists of an ancient and a novel intron position that are separated by less than 32 nt. Within a single gene, such closely-spaced introns are very unlikely to have coexisted. In most cases, therefore, the ancient intron position must have disappeared in favour of the novel one. A survey for NIPs among 12 Drosophila genomes identifies intron sliding (migration) as one of the more frequent causes of novel intron positions. Other novel introns seem to have been gained by regional tandem duplications of coding sequences containing a proto-splice site.
conclusionsRecent intron gains sometimes appear to have arisen by duplication of exonic sequences and subsequent intronization of one of the copies. Intron migration and exon duplication together may account for a significant amount of novel intron positions in conserved coding sequences.
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