ArticleEvolution; international journal of organic evolution2010
Integrating evolutionary and functional approaches to infer adaptation at specific loci.
Article in Evolution; international journal of organic evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Biogeography and Climate Drive Population Divergence and Genomic Vulnerability in High Altitude Endemic Bird.Molecular ecology · 2026Article
- Integrative Genomics Refines Tissues, Candidate Genes and Putative Regulatory Links Involved in the Humic Adaptation of Keystone Freshwater Fish.Molecular ecology · 2025Article
- An allozyme polymorphism is associated with a large chromosomal inversion in the marine snailEvolutionary applications · 2023Article
- Genic distribution modelling predicts adaptation of the bank vole to climate change.Communications biology · 2022Article
- A comparative study of population genetic structure reveals patterns consistent with selection at functional microsatellites in common sunflower.Molecular genetics and genomics : MGG · 2022Article
- Highly Replicated Evolution of Parapatric Ecotypes.Molecular biology and evolution · 2021Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- High levels of functional divergence in toxicity towards prey among the venoms of individual pigmy rattlesnakes.Biology letters · 2019Article
- Population Genomic Analysis of a Pitviper Reveals Microevolutionary Forces Underlying Venom Chemistry.Genome biology and evolution · 2017Article
- Complexities of gene expression patterns in natural populations of an extremophile fish (Poecilia mexicana, Poeciliidae).Molecular ecology · 2017Article
- The colonization and divergence patterns of Brandt's vole (Lasiopodomys brandtii) populations reveal evidence of genetic surfing.BMC evolutionary biology · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.Nature ecology & evolution · 2017Article
- Detecting polygenic selection in marine populations by combining population genomics and quantitative genetics approaches.Current zoology · 2016Article
- Haplotype distribution and association of candidate genes with salt tolerance in Indian wild rice germplasm.Plant cell reports · 2016Article
- Cold adaptation increases rates of nutrient flow and metabolic plasticity during cold exposure in Drosophila melanogaster.Proceedings. Biological sciences · 2016Article
- Patterns of Genome-Wide Variation in Glossina fuscipes fuscipes Tsetse Flies from Uganda.G3 (Bethesda, Md.) · 2016Article
- Mechanisms Underlying Adaptation to Life in Hydrogen Sulfide-Rich Environments.Molecular biology and evolution · 2016Article
- Article
- Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.Advances in experimental medicine and biology · 2016Review
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2 authors.
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Abstract
Inferences about adaptation at specific loci are often exclusively based on the static analysis of DNA sequence variation. Ideally,population-genetic evidence for positive selection serves as a stepping-off point for experimental studies to elucidate the functional significance of the putatively adaptive variation. We argue that inferences about adaptation at specific loci are best achieved by integrating the indirect, retrospective insights provided by population-genetic analyses with the more direct, mechanistic insights provided by functional experiments. Integrative studies of adaptive genetic variation may sometimes be motivated by experimental insights into molecular function, which then provide the impetus to perform population genetic tests to evaluate whether the functional variation is of adaptive significance. In other cases, studies may be initiated by genome scans of DNA variation to identify candidate loci for recent adaptation. Results of such analyses can then motivate experimental efforts to test whether the identified candidate loci do in fact contribute to functional variation in some fitness-related phenotype. Functional studies can provide corroborative evidence for positive selection at particular loci, and can potentially reveal specific molecular mechanisms of adaptation.
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