ArticleThe Journal of infectious diseases2010
Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Prevalence and determinants of zoonotic malaria in the Greater Mekong Subregion (GMS) and Malaysia: systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis.Malaria journal · 2020Pooled it
- Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria.The Journal of infectious diseases · 2026Article
- Galectins in Protozoan Parasitic Diseases: Potential Applications in Diagnostics and Therapeutics.Cells · 2023Review
- Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.EBioMedicine · 2022Article
- Factors Associated with Malaria Infection among Head Porters in Agbogbloshie Market in the Greater Accra Region of Ghana.Journal of parasitology research · 2020Article
- Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia.JCI insight · 2018Article
- Blockage of Galectin-receptor Interactions by α-lactose Exacerbates Plasmodium berghei-induced Pulmonary Immunopathology.Scientific reports · 2016Article
- Mortality attributable to Plasmodium vivax malaria: a clinical audit from Papua, Indonesia.BMC medicine · 2014Article
- Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria.The Journal of experimental medicine · 2013Article
- Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.The Journal of infectious diseases · 2011Article
- A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.Malaria journal · 2010Article
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundAge and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis.
methodsWe tested the association between rs7291467, a single-nucleotide polymorphism (SNP) in the LTalpha-related gene encoding galectin-2 (LGALS2), disease severity, and function in a case-control study of ethnic Highland Papuan adults and children with SM (n = 380) and asymptomatic malaria-exposed controls (n = 356) originating from a non-malaria-endemic region but residing in a lowland malaria-endemic area of Papua, Indonesia.
resultsThe LGALS2 SNP showed a significant association with susceptibility to SM (including CM), in children (odds ratio, 2.02 [95% confidence interval, 1.14-3.57]) but not in adults. In SM, the C allele at rs7291467 was associated with enhanced galectin-2 transcript levels. In a separate group of Tanzanian children originating from a malaria-endemic region, we found preservation of the major ancestral LGALS2 allele and no association with susceptibility to CM.
conclusionsResults suggest differences in the inflammatory contribution to the development of SM between children and adults in the same population and potential differences between individuals originating from malaria-endemic and non-malaria-endemic areas.
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