ArticleCancer2010
Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study.
Article in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 153 citations in OpenAlex.
- Trial
- Does Subspecialization Matter? Institutional Outcomes Before and After Recruitment of Colorectal Surgeons.World journal of surgery · 2026Article
- Understanding Textbook outcome failure after robotic colorectal cancer surgery: a multicenter domain-specific analysis.Journal of robotic surgery · 2026Observational
- Optimizing lymph node harvest in laparoscopic colorectal cancer: predictors and station-specific lymph node submission solutions.Annals of coloproctology · 2026Article
- Quantitative parameters of dual-layer spectral CT for differentiating metastatic and non-metastatic lymph nodes in colorectal cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Clinicopathologic Determinants of Lymph Node Count and Prognostic Significance of Metastatic Lymph Node Ratio in Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- Lymph Nodal Yield and Pattern of Spread in Carcinoma Rectum: A Study on Non-formalin Fixed Freshly Resected Surgical Specimen Dissection.Indian journal of surgical oncology · 2025Article
- Optimal lymph node yield for long-term survival in elderly patients with right-sided colon cancer: a large population-based cohort study.BMC cancer · 2025Article
- Comparison of proximal and distal gastric neuroendocrine carcinoma based on SEER database.Scientific reports · 2024Article
- The benefit of adjuvant chemotherapy in pathological T1-3N0M0 rectal mucinous adenocarcinoma: no improvement survival outcomes based on long-term survival analysis of large population data.Journal of gastrointestinal oncology · 2024Article
- The Relationship Between DNA Mismatch Repair Status and Clinicopathologic Characteristics in Colon Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Impact of lymph node retrieval on prognosis in elderly and non-elderly patients with T3-4/N+ rectal cancer following neoadjuvant therapy: a retrospective cohort study.International journal of colorectal disease · 2024Article
- Lymph node ratio is a more robust predictor of overall survival than N stage in stage III colorectal adenocarcinoma.Diagnostic pathology · 2024Review
- Article
- Endoscopic obstruction predominantly occurs in right-side colon cancer and endoscopic obstruction with tumor size ≤ 5 cm seems poor prognosis in colorectal cancer.Frontiers in oncology · 2024Article
- Immune microenvironment and lymph node yield in colorectal cancer.British journal of cancer · 2023Article
- Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis.Surgery in practice and science · 2023Review
- Adrenal Metastasectomy in the Era of Immuno- and Targeted Therapy.Annals of surgical oncology · 2023Review
- Rectal Cancer: Are 12 Lymph Nodes the Limit?Cancers · 2023Article
- Preoperative endoscopic tattoo marking improves lymph node retrieval in laparoscopic rectal resection: a retrospective cohort study.Annals of coloproctology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe National Quality Forum endorses the recommendation of examining at least 12 lymph nodes (LNs) from colorectal cancer (CRC) specimens. However, heterogeneity in LN harvest exists. The objective of this study was to investigate the clinicopathologic factors that influence LN yield.
methodsThe authors used the Surveillance, Epidemiology, and End Results database to identify patients who were diagnosed with stage I, II, and III CRC between 1994 and 2005. Poisson regression was used to model the number of LNs examined as a function of individual clinicopathologic factors, including age, sex, race, year of diagnosis, geographic region, anatomic site, preoperative radiation, tumor size, tumor classification, tumor differentiation, and LN positivity.
resultsIn total, 153,483 patients with CRC were identified. The mean number of LNs examined (+/- standard deviation) was 12 (+/-9.3). Separate multivariate analyses revealed that age, year of diagnosis, tumor size, and tumor classification were significant predictors of LN yield for colon and extraperitoneal rectal cancers (P < .01 for all covariates). Tumor location and radiotherapy were significant predictors of LN yield in patients with colon cancer and rectal cancer, respectively. Overall LN yields increased between 2% and 3% annually.
conclusionsDespite the increasing yields observed over time, patients with rectal cancer and older patients who had distally located, early colon cancer were less likely to meet the benchmark yield of 12 LNs. Further investigation into how LN yield is influenced by alterable factors, such as the extent of mesenteric resection and the pathologic technique, as well as nonalterable factors, such as patient age and tumor location, may reveal innovative ways to improve current staging methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.