ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2010
Systemic effects of ulna loading in male rats during functional adaptation.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Skeletal impacts of dual in vivo compressive axial tibial and ulnar loading in mice.Journal of the mechanical behavior of biomedical materials · 2025Article
- Management of Long Bone Fractures in Two Dogs Using 4.5mm Dynamic Compression Plates.Case reports in veterinary medicine · 2025Article
- A Novel Ex Vivo Bone Culture Model for Regulation of Collagen/Apatite Preferential Orientation by Mechanical Loading.International journal of molecular sciences · 2022Article
- Axial mechanical loading toBone reports · 2021Article
- A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing spatiotemporal delivery of bone morphogenic protein-2 and zoledronic acid.Science advances · 2020Article
- Lasting organ-level bone mechanoadaptation is unrelated to local strain.Science advances · 2020Article
- Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- The Role of Nerves in Skeletal Development, Adaptation, and Aging.Frontiers in endocrinology · 2020Review
- Moderate tibia axial loading promotes discordant response of bone composition parameters and mechanical properties in a hindlimb unloading rat model.Journal of musculoskeletal & neuronal interactions · 2018Article
- Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.PloS one · 2018Article
- Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model.Journal of orthopaedic translation · 2017Article
- Mechanical Loading Attenuates Radiation-Induced Bone Loss in Bone Marrow Transplanted Mice.PloS one · 2016Article
- Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats.Experimental gerontology · 2015Article
- In vivo axial loading of the mouse tibia.Methods in molecular biology (Clifton, N.J.) · 2015Article
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- Self-repair of rat cortical bone microdamage after fatigue loading in vivo.International journal of endocrinology · 2013Article
- Adaptive and Injury Response of Bone to Mechanical Loading.BoneKEy osteovision · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Functional skeletal adaptation is thought to be a local phenomenon controlled by osteoctyes. However, the nervous system also may have regulatory effects on adaptation. The aim of this study was to determine the effects of loading of a single bone on adaptation of other appendicular long bones and whether these responses were neuronally regulated. Young male Sprague-Dawley rats were used. The right ulna was loaded to induce a modeling response. In other rats, a second regimen was used to induce bone fatigue with a mixed modeling/remodeling response; a proportion of rats from each group received brachial plexus anesthesia to induce temporary neuronal blocking during bone loading. Sham groups were included. Left and right long bones (ulna, humerus, tibia, and femur) from each rat were examined histologically 10 days after loading. In fatigue- and sham-loaded animals, blood plasma concentrations of TNF-α, RANKL, OPG, and TRAP5b were determined. We found that loading the right ulna induced an increase in bone formation in distant long bones that were not loaded and that this effect was neuronally regulated. Distant effects were most evident in the rats that received loading without bone fatigue. In the fatigue-loaded animals, neuronal blocking induced a significant decrease in plasma TRAP5b at 10 days. Histologically, bone resorption was increased in both loaded and contralateral ulnas in fatigue-loaded rats and was not significantly blocked by brachial plexus anesthesia. In young, growing male rats we conclude that ulna loading induced increased bone formation in multiple bones. Systemic adaptation effects were, at least in part, neuronally regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.