ArticleJournal of assisted reproduction and genetics2010
No mitochondrial DNA deletions but more D-loop point mutations in repeated pregnancy loss.
Article in Journal of assisted reproduction and genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Polystyrene Nanoparticles Disrupt Oxidative Phosphorylation and Impair Placental Development in Mice.Toxics · 2026Article
- Mitochondrial dysfunction in pregnancy loss: a review.Molecular and cellular biochemistry · 2025Review
- Review
- Mitochondrial DNA Copy Number in Cleavage Stage Human Embryos-Impact on Infertility Outcome.Current issues in molecular biology · 2022Article
- Mitochondrial DNA in Fresh versus Frozen Embryo Culture Media of Polycystic Ovarian Syndrome Patients Undergoing Invitro Fertilization: A Possible Predictive Marker of a Successful Pregnancy.Pharmacogenomics and personalized medicine · 2021Article
- Deep sequencing shows that accumulation of potentially pathogenic mtDNA mutations rather than mtDNA copy numbers may be associated with early embryonic loss.Journal of assisted reproduction and genetics · 2020Article
- Deleterious mtDNA mutations are common in mature oocytes.Biology of reproduction · 2020Article
- Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors.Cell journal · 2019Article
- Association of genetic variations in the mitochondrial DNA control region with presbycusis.Clinical interventions in aging · 2017Article
- Mitochondrial Copy Number and D-Loop Variants in Pompe Patients.Cell journal · 2016Article
- The mitochondrial C16069T polymorphism, not mitochondrial D310 (D-loop) mononucleotide sequence variations, is associated with bladder cancer.Cancer cell international · 2013Article
- Genetics of recurrent miscarriage: challenges, current knowledge, future directions.Frontiers in genetics · 2012Article
- A Review on Various Uses of N-Acetyl Cysteine.Cell journalReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposerepeated pregnancy loss (RPL) occurs in 1 out of 300 couples, and the cause of about 50% of them remains idiopathic. Mitochondria have an important role in human development through ATP production and their involvement in apoptosis.
methods96 RPL and 96 control females were used to investigate the frequency of deletions and point mutations in the displacement loop (D-loop) on mitochondria. Multiplex PCR and DNA sequencing methods were used to detect possible variations in the mitochondrial DNA (mtDNA).
resultsno deletions but a high frequency of point mutations were found in RPL females; among 129 variations observed in RPL, 22 mutations were significant (P < 0.05) and the insertion of C in nucleotide 114 was novel.
conclusionhigh rate of mutations in D-loop of mtDNA was observed in maternal blood, a fact that may have a direct or indirect role in inducing RPL. The results can be used in the assessment of RPL and designing possible treatments for improving assisted reproduction.
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Registered trials
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