ArticleClinical and experimental medicine2011
Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia.
Article in Clinical and experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Iron Deficiency and Iron Deficiency Anemia: A Comprehensive Overview of Established and Emerging Concepts.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia.Blood advances · 2025Article
- Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease.Journal of family medicine and primary care · 2025Article
- Prevalence and Risk Factors of Anemia in the MASHAD Cohort Study.Archives of Iranian medicine · 2023Article
- Evaluation of thyroid functions and obesity in obstructive sleep apnea syndrome.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Role of Hepcidin in Anemia of Chronic Disease in Rheumatoid Arthritis.Journal of laboratory physicians · 2021Article
- Association of gestational anemia with pregnancy conditions and outcomes: A nested case-control study.World journal of clinical cases · 2021Article
- Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.Frontiers in aging neuroscience · 2021Article
- Hepcidin and GDF-15 are potential biomarkers of iron deficiency anaemia in chronic kidney disease patients in South Africa.BMC nephrology · 2020Article
- Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study.Lipids in health and disease · 2019Article
- Impact of serum hepcidin and inflammatory markers on resistance to erythropoiesis-stimulating therapy in haemodialysis patients.International urology and nephrology · 2019Article
- Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients.Journal of inflammation (London, England) · 2017Article
- Hepcidin expression in psoriasis patients.Indian journal of dermatology · 2014Article
- [Serum hepcidin levels in geriatric patients with iron deficiency anemia or anemia of chronic diseases].Zeitschrift fur Gerontologie und Geriatrie · 2014Article
- The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease.Acta neuropathologica communications · 2013Article
- Anemia in relation to body mass index and waist circumference among Chinese women.Nutrition journal · 2013Article
- Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.Haematologica · 2011Article
- Iron deficiency in critically ill patients: highlighting the role of hepcidin.Critical care (London, England) · 2011Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepcidin is a key hormone governing mammalian iron homeostasis and may be directly or indirectly involved in the development of most iron deficiency/overload and inflammation-induced anemia. The objective of this study was to investigate the expression of hepcidin in anemia of chronic disease. To characterize serum hepcidin, iron and inflammatory indicators associated with anemia of chronic disease (ACD), we studied ACD, ACD concomitant iron-deficiency anemia (ACD/IDA), pure IDA and acute inflammation (AcI) patients and analyzed the associations between hepcidin levels and inflammation parameters in various types of anemia. Serum hepcidin levels in patient groups were statistically different, from high to low: ACD, AcI > ACD/IDA > the control > IDA. Serum ferritin levels were significantly increased in ACD and AcI patients but were decreased significantly in ACD/IDA and IDA. Elevated serum EPO concentrations were found in ACD, ACD/IDA and IDA patients but not in AcI patients and the controls. A positive correlation between hepcidin and IL-6 levels only existed in ACD/IDA, AcI and the control groups. A positive correlation between hepcidin and ferritin was marked in the control group, while a negative correlation between hepcidin and ferritin was noted in IDA. The significant negative correlation between hepcidin expression and reticulocyte count was marked in both ACD/IDA and IDA groups. All of these data demonstrated that hepcidin might play role in pathogenesis of ACD, ACD/IDA and IDA, and it could be a potential marker for detection and differentiation of these anemias.
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