ArticleAnti-inflammatory & anti-allergy agents in medicinal chemistry2009
Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity.
Article in Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178004 (Profiling Stool Cytokines and Microbiome of Infants With Non-IgE-mediated Cow's Milk Protein Allergy Could Explain Its Pathophysiology and be Used as a Non-invasive Diagnostic Method), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Profiling Stool Cytokines and Microbiome of Infants With Non-IgE-mediated Cow's Milk Protein Allergy Could Explain Its Pathophysiology and be Used as a Non-invasive Diagnostic Method (Melina Study)
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates.The Cochrane database of systematic reviews · 2016Pooled it
- Evidence-based guidelines for use of probiotics in preterm neonates.BMC medicine · 2011Pooled it
- Comparative study of preterm infants fed new and existing human milk fortifiers showed favourable markers of gastrointestinal status.Acta paediatrica (Oslo, Norway : 1992) · 2020Trial
- Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation.Research square · 2026Article
- Gastrointestinal emergencies and monitoring in preterm infants: a review.Annals of medicine · 2025Review
- A multidimensional fecal microbial and inflammatory biomarker profiling in preterm and full-term neonates.Pediatric research · 2025Observational
- Gut microbiome and inflammation in response to increasing intermittent hypoxia in the neonatal rat.Pediatric research · 2025Article
- Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis.Frontiers in immunology · 2025Article
- A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic.International journal of molecular sciences · 2024Review
- Despite Recovery from Necrotizing Enterocolitis Infants Retain a Hyperinflammatory Response to Injury.Journal of inflammation research · 2024Article
- Surveillance of Multidrug-Resistant Pathogens in Neonatal Intensive Care Units of Palermo, Italy, during SARS-CoV-2 Pandemic.Antibiotics (Basel, Switzerland) · 2023Article
- Time to first passage of meconium and defecation frequency preceding necrotizing enterocolitis in preterm infants: a case-control study.European journal of pediatrics · 2023Article
- Persistent Proclivity to a Proinflammatory State in a Human Enteroid Model of Necrotizing Enterocolitis.Surgical infections · 2023Article
- Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains.Nature microbiology · 2023Article
- Article
- Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.Frontiers in immunology · 2022Article
- Introducing multi-modal enteral medication reduced morbidity and mortality associated with necrotising enterocolitis.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Sialylated human milk oligosaccharides prevent intestinal inflammation by inhibiting toll like receptor 4/NLRP3 inflammasome pathway in necrotizing enterocolitis rats.Nutrition & metabolism · 2021Article
- Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract.Frontiers in physiology · 2021Review
- Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.