Evidence map›Paper›PMID 20498633›Full record

ArticleOncogene2010

Epstein-Barr virus latent membrane protein-2A-induced DeltaNp63alpha expression is associated with impaired epithelial-cell differentiation.

J A Fotheringham, S Mazzucca, N Raab-Traub

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Epstein-Barr virus infection and nasopharyngeal carcinoma.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  12. Review
  13. Article
  14. Review
  15. Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase.Experimental biology and medicine (Maywood, N.J.) · 2015
    Review
  16. Epstein-Barr virus latent genes.Experimental & molecular medicine · 2015
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J A FotheringhamDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S Mazzucca
N Raab-Traub
University of North Carolina at Chapel Hill · US

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Dirk P Dittmer · 1985 to 2026
$43.8M
EBV TRANSCRIPTION IN NASOPHARYNGEAL CARCINOMAR01CA032979 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAAB-TRAUB, NANCY JOAN · 1985 to 2014
$4.4M
Epstein-Barr Virus: Activation of WNTR01CA103634 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAAB-TRAUB, NANCY JOAN · 2004 to 2008
$1.6M
NCI NIH HHS CA103634NCI NIH HHS CA19014NCI NIH HHS CA32979NCI NIH HHS P01 CA019014NCI NIH HHS R01 CA032979NCI NIH HHS R01 CA103634
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is an oncogenic gamma-herpes virus associated with malignancies that develop in both lymphoid and epithelial cells including nasopharyngeal carcinoma (NPC). The EBV protein, latent membrane protein 2A (LMP2A), is expressed in NPC and can modulate epithelial proliferation, transformation and differentiation, and as such may promote malignancy. A key regulator of epithelial-cell differentiation is the transcription factor p63, a member of the p53 family. This study examines the potential contribution of p63 to LMP2A-mediated inhibition of epithelial-cell differentiation. Stable expression of LMP2A increased the protein level and stability of the DeltaNp63alpha isoform and in two epithelial cell lines, LMP2A interacted with DeltaNp63alpha under stable- and transient-expression systems. LMP2A and DeltaNp63alpha were localized to the cytoplasm and nuclear membrane and co-immunoprecipitated in the same fractions. Following induction of epithelial-cell differentiation by calcium, expression of differentiation markers was impaired in both DeltaNp63alpha- and LMP2A-expressing cells. Induction of p63alpha, association of p63alpha with LMP2A and impairment of differentiation required the PY and immunoreceptor tyrosine-based activation motif (ITAM) signaling motif of LMP2A. By associating with and being regulated by LMP2A, DeltaNp63alpha may function as a unique regulator of LMP2A effects on epithelial differentiation and contribute to EBV-associated epithelial cancers.

Indexed as

CalciumCell DifferentiationCell LineEpithelial CellsHumansTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsViral Matrix ProteinsCalciumEBV-associated membrane antigen, Epstein-Barr virusTP63 protein, humanTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsViral Matrix Proteins

Identifiers

PMID20498633
PMCPMC2912443
OpenAlexW1988979144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.