ArticleAntimicrobial agents and chemotherapy2010
Origin and dissemination across the Colombian Andes mountain range of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Spatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coast.Scientific reports · 2020Trial
- Antimalarial drug resistance inParasitology · 2026Article
- Tracking Plasmodium falciparum antimalarial resistance markers during a malaria pre-elimination period in the Pacific coast of South America.Scientific reports · 2025Article
- Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis.PLoS pathogens · 2022Article
- Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018.Malaria journal · 2022Article
- Molecular surveillance of anti-malarial resistance Pfdhfr and Pfdhps polymorphisms in African and Southeast Asia Plasmodium falciparum imported parasites to Wuhan, China.Malaria journal · 2020Article
- Genotypes and phenotypes of resistance in Ecuadorian Plasmodium falciparum.Malaria journal · 2019Article
- Evidence of Self-Medication with Chloroquine before Consultation for Malaria in the Southern Pacific Coast Region of Colombia.The American journal of tropical medicine and hygiene · 2019Article
- Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.Nature medicine · 2017Review
- Longitudinal analysis of Plasmodium falciparum genetic variation in Turbo, Colombia: implications for malaria control and elimination.Malaria journal · 2015Article
- Malaria and the mobile and migrant population in Cambodia: a population movement framework to inform strategies for malaria control and elimination.Malaria journal · 2015Article
- Deletion of Plasmodium falciparum Histidine-Rich Protein 2 (pfhrp2) and Histidine-Rich Protein 3 (pfhrp3) Genes in Colombian Parasites.PloS one · 2015Article
- Article
- Prevalence of gestational, placental and congenital malaria in north-west Colombia.Malaria journal · 2013Article
- Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region.BMC genetics · 2013Article
- Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti.Malaria journal · 2012Article
- Prospects for malaria elimination in non-Amazonian regions of Latin America.Acta tropica · 2012Article
- Malaria in selected non-Amazonian countries of Latin America.Acta tropica · 2012Article
- Malaria-related anaemia: a Latin American perspective.Memorias do Instituto Oswaldo Cruz · 2011Review
- Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The therapeutic efficacy of sulfadoxine-pyrimethamine (SP) in treating uncomplicated Plasmodium falciparum malaria is unevenly distributed in Colombia. The Andes mountain range separates regions in the west where malaria is endemic from those in the east and constitutes a barrier against gene flow and the dispersal of parasite populations. The distribution of dhfr and dhps genotypes of 146 P. falciparum samples from the eastern Amazon and Orinoco basins and Northwest and Southwest Pacific regions of Colombia was consistent with the documented levels of therapeutic efficacy of SP. The diversity of four dhfr- and dhps-linked microsatellites indicated that double- and triple-mutant alleles for both resistance loci have a single origin. Likewise, multilocus association genotypes, including two unlinked microsatellite loci, suggested that genetic exchanges between the eastern Orinoco and Northwest Pacific populations has taken place across the Andes, most probably via migration of infected people.
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