SynthesisClinical journal of the American Society of Nephrology : CJASN2010
Treatment options for sexual dysfunction in patients with chronic kidney disease: a systematic review of randomized controlled trials.
Synthesis in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Sexual dysfunction and effect on quality of life in chronic kidney disease: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Interventions for treating sexual dysfunction in patients with chronic kidney disease.The Cochrane database of systematic reviews · 2010Pooled it
- Trial
- The impact of nocturnal hemodialysis on sexual function.BMC nephrology · 2012Trial
- Nephrology Survey on Reproductive Health and Kidney Disease.Kidney international reports · 2026Article
- Unravelling sex-specific differences in autosomal dominant polycystic kidney disease: a multiorgan perspective.Clinical kidney journal · 2026Review
- Reproductive dysfunction in hemodialysis: endocrine mechanisms, clinical features, and therapeutic approaches.Renal failure · 2025Review
- Dialysis Organization Online Information on Kidney Failure Treatments: A Content Analysis Using Corpus Linguistics.Kidney medicine · 2022Article
- Management of Psychiatric Disorders in Patients with Chronic Kidney Diseases.Indian journal of psychiatry · 2022Article
- Hormonal (Im)Balance and Reproductive System's Disorders in Transplant Recipients-A Review.Biology · 2021Review
- Sexual Dysfunction Improvement after Kidney Transplantation: A Prospective Study in Men and Women.International journal of sexual health : official journal of the World Association for Sexual Health · 2021Article
- The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews.Frontiers in pharmacology · 2021Article
- Survival of Patients on Hemodialysis with Erectile Dysfunction.Medicina (Kaunas, Lithuania) · 2020Article
- Improving Sexual Function in People With Chronic Kidney Disease: A Narrative Review of an Unmet Need in Nephrology Research.Canadian journal of kidney health and disease · 2020Review
- Erectile dysfunction in renal failure and transplant patients.Translational andrology and urology · 2019Review
- Exploring NursEs lived Experience of Discussions about Sexual health, with kidney patients in Devon (NEEDS).Nursing open · 2018Article
- Gonadal dysfunction in chronic kidney disease.Reviews in endocrine & metabolic disorders · 2017Review
- Male Sexual Dysfunction and Chronic Kidney Disease.Frontiers in medicine · 2017Review
- Erectile dysfunction in chronic kidney disease: From pathophysiology to management.World journal of nephrology · 2015Review
- Chronic kidney disease and erectile dysfunction.World journal of nephrology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesSexual dysfunction is very common in patients with chronic kidney disease (CKD), but treatment options are limited. The benefits and harms of existing interventions for treatment of sexual dysfunction were assessed in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: MEDLINE (1966 to December 2008), EMBASE (1980 to December 2008), and the Cochrane Trial Registry (Issue 4 2008) were searched for parallel and crossover randomized and quasi-randomized trials. Treatment effects were summarized as mean differences (MD) or standardized mean difference (SMD) with 95% confidence intervals (CI) using a random effects model.
resultsFourteen trials (328 patients) were included. Phosphodiesterase-5 inhibitors (PDE5i) compared with placebo significantly increased the overall International Index of Erectile Function-5 (IIEF-5) score (three trials, 101 patients, MD 1.81, 95% CI 1.51 to 2.10), all of its individual domains, and the complete 15-item IIEF-5 (two trials, 80 patients, MD 10.64, 95% CI 5.32 to 15.96). End-of-treatment testosterone levels were not significantly increased by addition of zinc to dialysate (two trials, 22 patients, SMD 0.19 ng/dl, 95% CI -2.12 to 2.50), but oral zinc improved end-of-treatment testosterone levels. There was no difference in plasma luteinizing and follicle-stimulating hormone level at the end of the study period with zinc therapy.
conclusionsPDE5i and zinc are promising interventions for treating sexual dysfunction in CKD. Evidence supporting their routine use in CKD patients is limited. There is an unmet need for studying interventions for male and female sexual dysfunction in CKD considering the significant disease burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.