ArticleThe Journal of physiology2010
A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling.iScience · 2024Review
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Long-term memory in Staphylococcus aureus α-hemolysin ion channel kinetics.European biophysics journal : EBJ · 2023Article
- Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair.Current cardiology reports · 2021Review
- Reduced NaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities.Journal of molecular and cellular cardiology · 2020Article
- Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence.Biophysical journal · 2019Article
- A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.Frontiers in physiology · 2018Review
- Early somatic mosaicism is a rare cause of long-QT syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.Computers in biology and medicine · 2015Review
- Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.Scientific reports · 2015Article
- Optogenetic versus Electrical Stimulation of Human Cardiomyocytes: Modeling Insights.Biophysical journal · 2015Article
- Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells.Stem cells (Dayton, Ohio) · 2015Article
- Continuous-time control of alternans in long Purkinje fibers.Chaos (Woodbury, N.Y.) · 2014Article
- Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach.Frontiers in physiology · 2014Review
- Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber.PloS one · 2014Article
- Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.Circulation research · 2013Article
- Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.PLoS computational biology · 2013Article
- Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.The Journal of general physiology · 2013Article
- How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.The Journal of physiology · 2012Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Computer modelling has emerged as a particularly useful tool in understanding the physiology and pathophysiology of cardiac tissues. Models of ventricular, atrial and nodal tissue have evolved and include detailed ion channel kinetics and intercellular Ca(2+) handling. Purkinje fibre cells play a central role in the electrophysiology of the heart and in the genesis of cardiac arrhythmias. In this study, a new computational model has been constructed that incorporates the major membrane currents that have been isolated in recent experiments using Purkinje fibre cells. The model, which integrates mathematical models of human ion channels based on detailed biophysical studies of their kinetic and voltage-dependent properties, recapitulates distinct electrophysiological characteristics unique to Purkinje fibre cells compared to neighbouring ventricular myocytes. These characteristics include automaticity, hyperpolarized voltage range of the action potential plateau potential, and prolonged action potential duration. Simulations of selective ion channel blockade reproduce responses to pharmacological challenges characteristic of isolated Purkinje fibres in vitro, and importantly, the model predicts that Purkinje fibre cells are prone to severe arrhythmogenic activity in patients harbouring long QT syndrome 3 but much less so for other common forms of long QT. This new Purkinje cellular model can be a useful tool to study tissue-specific drug interactions and the effects of disease-related ion channel dysfunction on the cardiac conduction system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.