ArticleProceedings of the National Academy of Sciences of the United States of America2010
Process-based network decomposition reveals backbone motif structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Global stabilization of Boolean networks with applications to biomolecular network control.Scientific reports · 2025Article
- Reconstructing signed relations from interaction data.Scientific reports · 2023Article
- The Topological Characteristics of Biological Ratio-Sensing Networks.Life (Basel, Switzerland) · 2023Article
- Identification of dynamic driver sets controlling phenotypical landscapes.Computational and structural biotechnology journal · 2022Article
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- TENET: gene network reconstruction using transfer entropy reveals key regulatory factors from single cell transcriptomic data.Nucleic acids research · 2021Article
- Analysis on gene modular network reveals morphogen-directed development robustness inCell discovery · 2020Article
- How causal analysis can reveal autonomy in models of biological systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Funneled potential and flux landscapes dictate the stabilities of both the states and the flow: Fission yeast cell cycle.PLoS computational biology · 2017Article
- Reconstructing the regulatory circuit of cell fate determination in yeast mating response.PLoS computational biology · 2017Article
- Dynamics and robustness of the cardiac progenitor cell induced pluripotent stem cell network during cell phenotypes transition.IET systems biology · 2017Article
- Boolean Models of Biological Processes Explain Cascade-Like Behavior.Scientific reports · 2016Article
- An Algorithm for Finding the Singleton Attractors and Pre-Images in Strong-Inhibition Boolean Networks.PloS one · 2016Article
- From Boolean Network Model to Continuous Model Helps in Design of Functional Circuits.PloS one · 2015Article
- Robustness and evolvability of the human signaling network.PLoS computational biology · 2014Article
- Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition.PloS one · 2013Article
- Network class superposition analyses.PloS one · 2013Article
- A reverse engineering approach to optimize experiments for the construction of biological regulatory networks.PloS one · 2013Article
- Article
- Discovery of a kernel for controlling biomolecular regulatory networks.Scientific reports · 2013Article
Corrections and comments
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7 authors.
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Abstract
A central challenge in systems biology today is to understand the network of interactions among biomolecules and, especially, the organizing principles underlying such networks. Recent analysis of known networks has identified small motifs that occur ubiquitously, suggesting that larger networks might be constructed in the manner of electronic circuits by assembling groups of these smaller modules. Using a unique process-based approach to analyzing such networks, we show for two cell-cycle networks that each of these networks contains a giant backbone motif spanning all the network nodes that provides the main functional response. The backbone is in fact the smallest network capable of providing the desired functionality. Furthermore, the remaining edges in the network form smaller motifs whose role is to confer stability properties rather than provide function. The process-based approach used in the above analysis has additional benefits: It is scalable, analytic (resulting in a single analyzable expression that describes the behavior), and computationally efficient (all possible minimal networks for a biological process can be identified and enumerated).
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