ArticleProceedings of the National Academy of Sciences of the United States of America2010
Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- How Big Is the Yeast Prion Universe?International journal of molecular sciences · 2023Review
- Biochemical Principles in Prion-Based Inheritance.Epigenomes · 2022Review
- The Hunt for Ancient Prions: Archaeal Prion-Like Domains Form Amyloid-Based Epigenetic Elements.Molecular biology and evolution · 2021Article
- Review
- Extracellular Vesicles-Encapsulated Yeast Prions and What They Can Tell Us about the Physical Nature of Propagons.International journal of molecular sciences · 2020Review
- The actin cytoskeletal network plays a role in yeast prion transmission and contributes to prion stability.Molecular microbiology · 2020Article
- RNA Sequencing Reveals Specific TranscriptomicSignatures Distinguishing Effects of the [Genes · 2019Article
- Evolutionary behaviour of bacterial prion-like proteins.PloS one · 2019Article
- Article
- Study of Amyloids Using Yeast.Methods in molecular biology (Clifton, N.J.) · 2018Article
- High-throughput Screening for Protein-based Inheritance in S. cerevisiae.Journal of visualized experiments : JoVE · 2017Article
- Epigenetic inheritance, prions and evolution.Journal of genetics · 2017Review
- Analysis of [SWIMolecular microbiology · 2017Article
- Prions, Chaperones, and Proteostasis in Yeast.Cold Spring Harbor perspectives in biology · 2017Review
- Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number.BMC genetics · 2016Article
- Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae.PLoS genetics · 2016Article
- Yeast and Fungal Prions.Cold Spring Harbor perspectives in biology · 2016Review
- Are there prions in plants?Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Prions, amyloids, and RNA: Pieces of a puzzle.Prion · 2016Review
- Prions are affected by evolution at two levels.Cellular and molecular life sciences : CMLS · 2016Review
3 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Four protein-based genetic determinants or prions-[SWI(+)], [MCA], [OCT(+)], and [MOT3(+)]-are recent additions to the list of well-known Saccharomyces cerevisiae prions, [PSI(+)], [URE3], and [PIN(+)]. A rapid expansion of this list may indicate that many yeast proteins can convert into heritable prion forms and underscores a problem of prion input into cellular physiology. Here, we prove that the global transcriptional regulator Sfp1 can become a prion corresponding to the prion-like determinant [ISP(+)] described earlier. We show that SFP1 deletion causes an irreversible [ISP(+)] loss, whereas increased SFP1 expression induces [ISP(+)] appearance. Cells that display the [ISP(+)] phenotype contain the aggregated form of Sfp1. Indeed, these aggregates demonstrate a nuclear location. We also show that the phenotypic manifestation of Sfp1 prionization differs from the manifestation of SFP1 deletion. These properties and others distinguish [ISP(+)] from yeast prions described to date.
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