ArticleProceedings of the National Academy of Sciences of the United States of America2010
Control of bacterial iron homeostasis by manganese.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Manganese homeostasis supportsCurrent research in microbial sciences · 2026Article
- A previously uncharacterized Fur-family metalloregulator integrates iron- and manganese-sensing to control virulence gene regulatory networks in Brucella.Scientific reports · 2025Article
- Article
- Article
- Article
- PQS and pyochelin inMicrobiology spectrum · 2024Article
- Manganese Acts as an Environmental Inhibitor of Pseudomonas aeruginosa Biofilm Development by Inducing Dispersion and Modulating c-di-GMP and Exopolysaccharide Production via RbdA.Journal of bacteriology · 2023Article
- Manganese Utilization inFrontiers in cell and developmental biology · 2022Review
- Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport.Biochemistry · 2021Review
- T6SS Mediated Stress Responses for Bacterial Environmental Survival and Host Adaptation.International journal of molecular sciences · 2021Review
- Roles of Type VI Secretion System in Transport of Metal Ions.Frontiers in microbiology · 2021Review
- Mechanistic insights into heme-mediated transcriptional regulation via a bacterial manganese-binding iron regulator, iron response regulator (Irr).The Journal of biological chemistry · 2020Article
- Roles of TroA and TroR in Metalloregulated Growth and Gene Expression inJournal of bacteriology · 2020Article
- Impact of Different Trace Elements on the Growth and Proteome of Two Strains ofFrontiers in microbiology · 2020Article
- Enniatin A1, A Natural Compound with Bactericidal Activity againstMolecules (Basel, Switzerland) · 2019Article
- Synergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter duringInfection and immunity · 2019Article
- Siderophore-Mediated Iron Acquisition Enhances Resistance to Oxidative and Aromatic Compound Stress inApplied and environmental microbiology · 2019Article
- Manganese scavenging and oxidative stress response mediated by type VI secretion system inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae.Infection and immunity · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Perception and response to nutritional iron availability by bacteria are essential to control cellular iron homeostasis. The Irr protein from Bradyrhizobium japonicum senses iron through the status of heme biosynthesis to globally regulate iron-dependent gene expression. Heme binds directly to Irr to trigger its degradation. Here, we show that severe manganese limitation created by growth of a Mn(2+) transport mutant in manganese-limited media resulted in a cellular iron deficiency. In wild-type cells, Irr levels were attenuated under manganese limitation, resulting in reduced promoter occupancy of target genes and altered iron-dependent gene expression. Irr levels were high regardless of manganese availability in a heme-deficient mutant, indicating that manganese normally affects heme-dependent degradation of Irr. Manganese altered the secondary structure of Irr in vitro and inhibited binding of heme to the protein. We propose that manganese limitation destabilizes Irr under low-iron conditions by lowering the threshold of heme that can trigger Irr degradation. The findings implicate a mechanism for the control of iron homeostasis by manganese in a bacterium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.