ArticleProceedings of the National Academy of Sciences of the United States of America2010
Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Autophagy in Tissue Repair and Regeneration.Cells · 2025Review
- Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis.Cell communication and signaling : CCS · 2024Article
- Atg2 Regulates Cellular and Humoral Immunity inInsects · 2023Article
- Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation.Science China. Life sciences · 2023Article
- The core autophagy protein ATG9A controls dynamics of cell protrusions and directed migration.The Journal of cell biology · 2022Article
- Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy.Analytical cellular pathology (Amsterdam) · 2022Article
- p53 Related Protein Kinase is Required for Arp2/3-Dependent Actin Dynamics of Hemocytes inFrontiers in cell and developmental biology · 2022Article
- Review
- Metabolic Regulation of Thymic Epithelial Cell Function.Frontiers in immunology · 2021Review
- STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction.iScience · 2020Article
- On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells.Scientific reports · 2020Article
- Impaired Autophagy in the Fibroblasts by Titanium Particles Increased the Release of CX3CL1 and Promoted the Chemotactic Migration of Monocytes.Inflammation · 2020Article
- The Multifaceted Effects of Autophagy on the Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.Cell communication and signaling : CCS · 2018Article
- Functions of autophagy in the tumor microenvironment and cancer metastasis.The FEBS journal · 2018Review
- Basal autophagy is required for promoting dendritic terminal branching in Drosophila sensory neurons.PloS one · 2018Article
- Autophagy in cancer metastasis.Oncogene · 2017Review
- Article
- Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility.PloS one · 2016Article
- How and why to study autophagy in Drosophila: it's more than just a garbage chute.Methods (San Diego, Calif.) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dynamic regulation of cell shape underlies many developmental and immune functions. Cortical remodeling is achieved under the central control of Rho GTPase pathways that modulate an exquisite balance in the dynamic assembly and disassembly of the cytoskeleton and focal adhesions. Macroautophagy (autophagy), associated with bulk cytoplasmic remodeling through lysosomal degradation, has clearly defined roles in cell survival and death. Moreover, it is becoming apparent that proteins, organelles, and pathogens can be targeted for autophagic clearance by selective mechanisms, although the extent and roles of such degradation are unclear. Here we report a conserved role for autophagy specifically in the cortical remodeling of Drosophila blood cells (hemocytes) and mouse macrophages. Continuous autophagy was required for integrin-mediated hemocyte spreading and Rho1-induced cell protrusions. Consequently, hemocytes disrupted for autophagy were impaired in their recruitment to epidermal wounds. Cell spreading required ref(2)P, the Drosophila p62 multiadaptor, implicating selective autophagy as a novel mechanism for modulating cortical dynamics. These results illuminate a specific and conserved role for autophagy as a regulatory mechanism for cortical remodeling, with implications for immune cell function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.