Evidence map›Paper›PMID 20497921›Full record

Trial reportClinical breast cancer2010

Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial.

Luke J Peppone, Karen M Mustian, Michelle C Janelsins, Oxana G Palesh, Randy N Rosier, Kenneth M Piazza, Jason Q Purnell, Tom V Darling, Gary R Morrow

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical breast cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01880996 (The Effect of Tai-chi/Qi-gong on Quality of Life), which is not on this map. Cited by 35 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 9 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01880996 phase1 / phase2withdrawnnot on this mapstarted 2014, after this paper: background citation

The Effect of Tai-chi/Qi-gong on Quality of Life (QOL), Sleep, and Fatigue in Patients With Gynecological Malignancies

TypeinterventionalSponsorSheba Medical CenterRan2014 to 2015Enrolled0ConditionsOvarian Cancer, Primary Peritoneal Cancer, Other Gynecological CancersArmsTai-chi/Qi-gong
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 9 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  6. The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  7. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luke J PepponeDepartment of Radiation Oncology, University of Rochester Medical Center, NY 14642, USA. luke_peppone@urmc.rochester.edu <luke_peppone@urmc.rochester.edu>
Karen M Mustian
Michelle C Janelsins
Oxana G Palesh
Randy N Rosier
Kenneth M Piazza
Jason Q Purnell
Tom V Darling
Gary R Morrow
University of Rochester Medical Center · USRoswell Park Comprehensive Cancer Center · US

Funding

UNIVERSITY OF ROCHESTER--CCOP RESEARCH BASEU10CA037420 · NCI · UNIVERSITY OF ROCHESTER · PI MORROW, GARY R · 1985 to 2014
$21.1M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
NCI NIH HHS 1R25-CA102618-01A1NCI NIH HHS R25 CA102618NCI NIH HHS U10 CA037420
6 · The paper itself

Abstract

purposeTreatments for breast cancer, specifically hormonal therapy, accelerate bone loss (BL) among breast cancer survivors, leading to osteoporosis and an increase in fracture risk. Tai Chi Chuan (TCC) is a moderate form of weight-bearing exercise, equivalent to walking, and it has been shown to improve aerobic capacity and strength among breast cancer survivors and might also be effective in slowing bone loss in breast cancer survivors. This pilot study compared the influence of TCC with that of standard support therapy (ST; exercise control) on BL biomarkers among breast cancer survivors. PATIENTS AND

methodsRandomly assigned breast cancer survivors (N = 16; median age, 53 years; < 30 months after treatment) completed 12 weeks (3 times per week, 60 minutes per session) of TCC or ST. Serum levels of N-telopeptides of type I collagen (NTx), a marker of bone resorption, and bone-specific alkaline phosphatase (BSAP), a marker of bone formation, were determined according to enzyme-linked immunosorbent assay at baseline and after the intervention.

resultsUsing analysis of covariance, survivors in the TCC group experienced a greater increase in levels of bone formation (BSAP [microg/L]: before, 8.3; after, 10.2; change, 1.9 microg/L and 22.4%), compared with survivors in ST (BSAP [microg/L]: before, 7.6; after, 8.1; change, 0.5 microg/L [6.3%]). Survivors in the TCC group also experienced a significant decrease in bone resorption (NTx [nanomoles bone collagen equivalent; nmBCE]: before, 17.6; after, 11.1; change, -6.5 nmBCE; -36.9%), whereas women in the ST group did not (NTx [nmBCE]: before, 20.8; after, 18.8; change, -2.0 nmBCE; -9.6%).

conclusionThis pilot study suggests that weight-bearing exercise exerts positive effects on BL, through increased bone formation and decreased bone resorption. Further examinations of the influence of TCC on bone health are warranted.

Indexed as

Resistance TrainingSurvivorsTai JiBiomarkersBone and BonesBone ResorptionBreast NeoplasmsCollagen Type IFeasibility StudiesFemaleHumansMiddle AgedOsteoporosisPeptidesBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptidePeptides

Identifiers

PMID20497921
PMCPMC3071508
OpenAlexW2022904647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.