Evidence map›Paper›PMID 20497607›Full record

ArticleCritical care (London, England)2010

Does proteolysis explain glutamine release from the septic brain?

Cornelius H C Dejong, Steven W M Olde Damink

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Cornelius H C DejongDepartment of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University and University Hospital Maastricht, 6202 AZ Maastricht, the Netherlands. chc.dejong@ah.unimaas.nl
Steven W M Olde Damink
Maastricht University · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen.

Indexed as

Amino Acids, Branched-ChainBrainGlutamineHumansLipopolysaccharidesPeptide HydrolasesSepsisAmino Acids, Branched-ChainGlutamineLipopolysaccharidesPeptide Hydrolases

Identifiers

PMID20497607
PMCPMC2911689
OpenAlexW2022582292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.