ArticleArthritis research & therapy2010
Transcriptional profiling of the nucleus pulposus: say yes to notochord.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The Cellular Composition of Bovine Coccygeal Intervertebral Discs: A Comprehensive Single-Cell RNAseq Analysis.International journal of molecular sciences · 2021Article
- The mechano-response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent.JOR spine · 2020Article
- Skull base chordomas review of current treatment paradigms.World journal of otorhinolaryngology - head and neck surgery · 2020Review
- Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.Current stem cell research & therapy · 2015Review
- Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia.BMC musculoskeletal disorders · 2014Article
- Fish is Fish: the use of experimental model species to reveal causes of skeletal diversity in evolution and disease.Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology · 2014Article
- Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development.Arthritis research & therapy · 2013Article
- The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2012Article
- Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient mice.Spine · 2011Article
- The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Degeneration and regeneration of the intervertebral disc: lessons from development.Disease models & mechanisms · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of profiling studies by Minogue and colleagues. In their report of several marker genes that distinguish nucleus pulposus cells from other related cell types, the authors provide novel insights into the notochordal nature of the former. Together with recently published work, their work lends support to the view that all cells present within the nucleus pulposus are derived from the notochord. Hence, the choice of an animal model for disc research should be based on considerations other than the cell loss and replacement by non-notochordal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.