ArticleBiology direct2010
Genome factor and gene pleiotropy hypotheses in protein evolution.
Article in Biology direct, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Cell Compartment is a Predictor of Protein Rate of Evolution, but not in the Manner Expected: Evidence Against the Extended Complexity Hypothesis.Genome biology and evolution · 2025Article
- dJournal of molecular evolution · 2022Article
- A Simple Evolutionary Model of Genetic Robustness After Gene Duplication.Journal of molecular evolution · 2022Article
- Genepleio software for effective estimation of gene pleiotropy from protein sequences.BioMed research international · 2015Article
- Pleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.Genetics · 2014Article
- Enzyme recruitment and its role in metabolic expansion.Biochemistry · 2014Review
- Three independent determinants of protein evolutionary rate.Journal of molecular evolution · 2013Review
- Organ evolution in angiosperms driven by correlated divergences of gene sequences and expression patterns.The Plant cell · 2013Article
- Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins.Biology direct · 2011Article
- Article
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Authors and funding
2 authors.
Funding
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Abstract
The debate of genomic correlations between sequence conservation, protein connectivity, gene essentiality and gene expression, has generated a number of new hypotheses that are challenging the classical framework of molecular evolution. For instance, the translational selection hypothesis claims that the determination of the rate of protein evolution is the protein stability to avoid the misfolding toxicity. In this short article, we propose that gene pleiotropy, the capacity for affecting multiple phenotypes, may play a vital role in molecular evolution. We discuss several approaches to testing this hypothesis.
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