Evidence map›Paper›PMID 20496375›Full record

ReviewHuman brain mapping2010

Imaging genetics and development: challenges and promises.

B J Casey, Fatima Soliman, Kevin G Bath, Charles E Glatt

Open access · greenAbstract readReview
In one paragraph

Review in Human brain mapping, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Spatially Weighted Principal Component Analysis for Imaging Classification.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2015
    Article
  6. Environmental and Genetic Influences on Neurocognitive Development: The Importance of Multiple Methodologies and Time-Dependent Intervention.Clinical psychological science : a journal of the Association for Psychological Science · 2014
    Article
  7. Review
  8. Review
  9. Tensor Regression with Applications in Neuroimaging Data Analysis.Journal of the American Statistical Association · 2013
    Article
  10. Review
  11. Review
  12. Genetically informative research on adolescent substance use: methods, findings, and challenges.Journal of the American Academy of Child and Adolescent Psychiatry · 2010
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

B J CaseyDepartment of Psychiatry, Sackler Institute, Weill Cornell Medical College, New York, New York, USA. bjc2002@med.cornell.edu
Fatima Soliman
Kevin G Bath
Charles E Glatt
Cornell University · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Statistical Genetics Core: Impact of BDNF Genotype and Stress on LearningP50MH079513 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASEY, BETTY J · 2008 to 2012
$9.4M
Developing Researchers in Neuropsychiatric ImagingR25MH060478 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASEY, BETTY J · 1999 to 2008
$2.3M
NIGMS NIH HHS GM07739NIGMS NIH HHS T32 GM007739NIMH NIH HHS MH060478NIMH NIH HHS MH079513NIMH NIH HHS P50 MH079513NIMH NIH HHS R25 MH060478
6 · The paper itself

Abstract

Excitement with the publication of the human genome has served as catalyst for scientists to uncover the functions of specific genes. The main avenues for understanding gene function have been in behavioral genetics on one end and on the other end, molecular mouse models. Attempts to bridge these approaches have used brain imaging to conveniently link anatomical abnormalities seen in knockout/transgenic mouse models and abnormal patterns of brain activity seen in humans. Although a convenient approach, this article provides examples of challenges for imaging genetics, its application to developmental questions, and promises for future directions. Attempts to link genes, brain, and behavior using behavioral genetics, imaging genetics, and mouse models of behavior are described. Each of these approaches alone, provide limited information on gene function in complex human behavior, but together, they are forming bridges between animal models and human psychiatric disorders.

Indexed as

AnimalsBehaviorBrainDiagnostic ImagingGenetics, BehavioralHumansModels, Neurological

Identifiers

PMID20496375
PMCPMC3081635
OpenAlexW2120425068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.