ArticleCellular and molecular life sciences : CMLS2010
Calcineurin activity is required for the completion of cytokinesis.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- A multivalent docking platform and Rcn1-mediated inhibition control the extent of calcineurin recruitment to the cell division site for the dephosphorylation of multiple cytokinetic proteins.bioRxiv : the preprint server for biology · 2026Article
- Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025Review
- A localized calcium transient and polar body abscission.Cell cycle (Georgetown, Tex.) · 2022Article
- Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer.International journal of molecular sciences · 2020Review
- NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal CaThe EMBO journal · 2020Article
- Dynamin 2 is essential for mammalian spermatogenesis.Scientific reports · 2016Article
- Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair.The Journal of cell biology · 2015Article
- IQGAP1 is associated with nuclear envelope reformation and completion of abscission.Cell cycle (Georgetown, Tex.) · 2015Article
- Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.Cell cycle (Georgetown, Tex.) · 2014Article
- Mitotic inhibition of clathrin-mediated endocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Protein adaptation: mitotic functions for membrane trafficking proteins.Nature reviews. Molecular cell biology · 2013Review
- Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.Molecular cancer · 2013Article
- Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.PloS one · 2013Article
- Peptidyl-prolyl isomerization for cytokinetic abscission: fold and cut.Cell cycle (Georgetown, Tex.) · 2012Article
- Mitotic moonlighting functions for membrane trafficking proteins.Traffic (Copenhagen, Denmark) · 2011Review
- Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.Molecular cancer · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful completion of cytokinesis requires the spatio-temporal regulation of protein phosphorylation and the coordinated activity of protein kinases and phosphatases. Many mitotic protein kinases are well characterized while mitotic phosphatases are largely unknown. Here, we show that the Ca(2+)- and calmodulin-dependent phosphatase, calcineurin (CaN), is required for cytokinesis in mammalian cells, functioning specifically at the abscission stage. CaN inhibitors induce multinucleation in HeLa cells and prolong the time cells spend connected via an extended intracellular bridge. Upon Ca(2+) influx during cytokinesis, CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II (dynII). At the intracellular bridge, phospho-dynII and CaN are co-localized to dual flanking midbody rings (FMRs) that reside on either side of the central midbody ring. CaN activity and disassembly of the FMRs coincide with abscission. Thus, CaN activity at the midbody plays a key role in regulating the completion of cytokinesis in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.