Evidence map›Paper›PMID 20495984›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010

A systematic review of dysgeusia induced by cancer therapies.

Allan J Hovan, P Michele Williams, Peter Stevenson-Moore, Yula B Wahlin, Kirsten E O Ohrn, Linda S Elting, Fred K L Spijkervet, Michael T Brennan, Dysgeusia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03210441 (Evaluation of Eating Habits and Dysgeusia During Chemotherapy Treatment), which is not on this map. Cited by 107 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03210441 unknown statusnot on this mapstarted 2014, after this paper: background citation

Evaluation of Eating Habits and Dysgeusia During Chemotherapy Treatment: a Prospective Cohort Study on Patients Affected by Breast Cancer

TypeobservationalSponsorAzienda Socio Sanitaria Territoriale degli Spedali Civili di BresciaRan2014 to 2018Enrolled204ConditionsBreast Cancer, Dysgeusia, Eating Behavior, Quality of Life
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Metallic taste prevalence in patients treated for cancer: a systematic literature review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  2. Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  3. Pooled it
  4. The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  5. Interventions for managing taste disturbances.The Cochrane database of systematic reviews · 2017
    Pooled it
  6. Pooled it
  7. Acupuncture for chemotherapy-induced dysgeusia (AcuDysg): a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Effects of professional oral health care on reducing the risk of chemotherapy-induced oral mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Trial
  12. Observational
  13. Review
  14. Article
  15. Longitudinal assessment and predictors of subjective taste change after hematopoietic cell transplantation (HCT).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Eating Experiences of Patients With Cancer in the Hospital - A Qualitative Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  17. Comprehensive evaluation of taste dysfunction in allogeneic hematopoietic cell transplant recipients: a combined subjective and objective assessment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  18. Review
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Allan J HovanBC Cancer Agency, Vancouver, BC, Canada. ahovan@bccancer.bc.ca
P Michele Williams
Peter Stevenson-Moore
Yula B Wahlin
Kirsten E O Ohrn
Linda S Elting
Fred K L Spijkervet
Michael T Brennan
Dysgeusia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose was to review relevant scientific papers written since 1989 which focused on the prevalence and management of dysgeusia as an oral side effect of cancer treatment.

methodsOur literature search was limited to English language papers published between 1990 and 2008. A total of 30 papers were reviewed; the results of 26 of these papers were included in the present systematic review. A structured assessment form was used by two reviewers for each paper. Studies were weighted as to the quality of the study design, and treatment recommendations were based on the relative strength of each paper.

resultsA wide range in reported prevalence of dysgeusia was identified with the weighted prevalence from 56-76%, depending on the type of cancer treatment. Attempts to prevent dysgeusia through the prophylactic use of zinc sulfate or amifostine have been of limited benefit. Nutritional counseling may be helpful to some patients in minimizing the symptoms of dysgeusia.

conclusionsDysgeusia is a common oral side effect of cancer therapy (radiotherapy, chemotherapy, or combined modality therapy) and often impacts negatively on quality of life. From the current literature, there does not appear to be a predictable way of preventing or treating dysgeusia.

Indexed as

Quality of LifeAmifostineDysgeusiaHumansNeoplasmsPrevalenceZinc SulfateAmifostineZinc Sulfate

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.