ArticleEuropean radiology2010
Percutaneous isolated liver perfusion with occlusion balloons and a catheter-based stent-graft-like perfusion device: an experimental study in a porcine model.
Article in European radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01250158 (First In-vivo Trial of the Liver Percutaneous Isolated Localized Perfusion), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First In-vivo Trial of the Liver Percutaneous Isolated Localized Perfusion (PILP) Set for the Treatment of Liver Metastases
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Flushing out antibodies to make AAV gene therapy available to more patients.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the feasibility and safety of a novel percutaneous isolated liver perfusion (PILP) system in a porcine model.
methodsThe PILP catheter set, consisting of a portal vein and hepatic artery occlusion balloon and an hourglass-shaped vena cava stent-graft, was tested in six Dutch Landrace pigs. A veno-venous bypass between the distal portal vein and the right femoral vein, and isolated perfusion between the proximal portal vein and the hepatic veins were also created. Leak rate was determined using radioactivity measurement in the systemic circulation. Perfusion was then performed without (n = 2) or with cytotoxic drugs (n = 4). At the end of the procedure, all devices were retrieved and angiographic evaluation was performed of the involved vessel segments.
resultsIn all pigs it was possible to insert, accurately position and retrieve all components of the PILP catheter set without angiographic signs of vessel-wall damage. Leakage rates to the systemic circulation were less than 7% over the course of the perfusion.
conclusionIn a porcine model, the PILP system can be safely and accurately positioned, and showed successful vascular isolation of the liver, with a leak rate to the systemic circulation of less than 7%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.