Evidence map›Paper›PMID 20495939›Full record

ArticleClinical rheumatology2010

Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab.

Tobias Lahmer, Andreas Knopf, Matthias Treiber, Uwe Heemann, Klaus Thuermel

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Arthritic Microenvironment-Dictated Fate Decisions for Stem Cells in Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  2. Article
  3. Article
  4. Relapsing polychondritis: a chameleon among orphan diseases.Wiener medizinische Wochenschrift (1946) · 2017
    Review
  5. Relapsing polychondritis: a review.Clinical rheumatology · 2013
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tobias LahmerDepartment of Nephrology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaninger Str. 22, 81675, Munich, Germany. Tobias.Lahmer@lrz.tu-muenchen.de
Andreas Knopf
Matthias Treiber
Uwe Heemann
Klaus Thuermel
Klinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapsing polychondritis (RP) is a rare immune-mediated disease which is associated with inflammation in cartilaginous tissue throughout the body. Especially, the cartilaginous structures of ear, respiratory tract, nose, and joints are affected. Around 30% of the cases are associated with other diseases especially systemic vasculitis. Onset of RP is most likely between the ages of 40-60 years. This case reports the often disguised and similar symptoms of RP to Wegner's granulomatosis and the challenge of diagnosis. The relative rarity of RP has not permitted clinical trials to determine the efficacy and safety of different therapies. Current treatment is largely empiric and based on case reports. In this case, we successfully used a treatment with the TNF-alpha antagonist adalimumab.

Indexed as

AdalimumabAgedAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsCartilageCartilage DiseasesDiagnosis, DifferentialEar DiseasesGranulomatosis with PolyangiitisHumansMalePolychondritis, RelapsingRadionuclide ImagingTreatment OutcomeTumor Necrosis Factor-alphaAdalimumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsTumor Necrosis Factor-alpha

Identifiers

PMID20495939
OpenAlexW2050985001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.