ArticleCurrent atherosclerosis reports2010
Hyperlipidemia and primary prevention of stroke: does risk factor identification and reduction really work?
Article in Current atherosclerosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prevalence and incidence of stroke, white matter hyperintensities, and silent brain infarcts in patients with chronic heart failure: A systematic review, meta-analysis, and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- The lipid-modulating effect of berberine in hyperlipidemic ApoE-/- mice.Frontiers in pharmacology · 2026Article
- Assessing the real-world safety of fenofibric acid for hyperlipidemia: results from WHO-VigiAccess and FAERS databases.Frontiers in medicine · 2025Article
- Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China.BMC cardiovascular disorders · 2022Article
- Article
- Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats.BioMed research international · 2017Article
- Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study.International journal of chronic obstructive pulmonary disease · 2017Article
- Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats.BMC complementary and alternative medicine · 2016Article
- Relationship between dyslipidemia and carotid plaques in a high-stroke-risk population in Shandong Province, China.Brain and behavior · 2016Article
- Human resources, patient load, and infrastructure at institutions providing diabetic care in India: The India 11-city 9-state study.Indian journal of endocrinology and metabolism · 2016Article
- The Role of Statin Therapy for Primary Prevention: What is the Evidence?Current atherosclerosis reports · 2012Article
- SigCS base: an integrated genetic information resource for human cerebral stroke.BMC systems biology · 2011Article
- Emerging strategies in the treatment of poststroke depression and psychiatric distress in patients.Psychology research and behavior management · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is one of the leading causes of death. Hyperlipidemia is a major risk factor for stroke. The United States Preventive Service Task Force defines lipid screening guidelines. Treatment options of hyperlipidemia include lifestyle modifications and medical management. Statins have been shown to decrease lipids and exert a pleiotropic effect on intracranial vasculature and inflammatory modulators, leading to neuroprotection. Lower low-density lipoprotein and higher high-density lipoprotein levels are associated with decreased risk of stroke. Despite screening guidelines and evidence of the efficacy of statins, there are numerous barriers to maintaining adequate control of lipids.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.