ArticleCell and tissue research2010
Primary cilia disappear in rat podocytes during glomerular development.
Article in Cell and tissue research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Primary cilium disappearance in podocytes during vertebrate phylogeny revealed by array tomography.Cell and tissue research · 2025Article
- The intelligent podocyte: sensing and responding to a complex microenvironment.Nature reviews. Nephrology · 2025Review
- Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells.Science advances · 2023Article
- Crosstalk between the mTOR pathway and primary cilia in human diseases.Current topics in developmental biology · 2023Review
- Rho GTPases in kidney physiology and diseases.Small GTPases · 2022Article
- Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography.Frontiers in cell and developmental biology · 2021Article
- Nephrocytes are part of the spectrum of filtration epithelial diversity.Cell and tissue research · 2020Article
- Article
- The complexity of the cilium: spatiotemporal diversity of an ancient organelle.Current opinion in cell biology · 2018Review
- Evolutionary morphology of podocytes and primary urine-producing apparatus.Anatomical science international · 2017Review
- Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis.Pediatric nephrology (Berlin, Germany) · 2017Review
- Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.BMC developmental biology · 2016Article
- The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.Journal of the American Society of Nephrology : JASN · 2015Article
- Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.Scientific reports · 2015Article
- Article
- Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation.PloS one · 2015Article
- A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.Journal of the American Society of Nephrology : JASN · 2014Article
- Dysfunction of intraflagellar transport proteins beyond the primary cilium.Journal of the American Society of Nephrology : JASN · 2014Article
- Planar cell polarity and the kidney.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most tubular epithelial cell types express primary cilia, and mutations of primary-cilium-associated proteins are well known to cause several kinds of cystic renal disease. However, until now, it has been unclear whether mammalian podocytes express primary cilia in vivo. In this study, we determined whether primary cilia are present in the podocytes of rat immature and mature glomeruli by means of transmission electron microscopy of serial ultrathin sections. In immature glomeruli of fetal rats, podocytes express the primary cilia with high percentages at the S-shaped body (88 +/- 5%, n = 3), capillary loop (95 +/- 4%, n = 4), and maturing glomerulus (76 +/- 13%, n = 5) stages. The percentage of ciliated podocytes was significantly lower at the maturing glomerulus stage than at the former two stages. In mature glomeruli of adult rats, ciliated podocytes were not found at all (0 +/- 0%, n = 11). These findings indicate that the primary cilia gradually disappear in rat podocytes during glomerular development. Since glomerular filtration rate increases during development, the primary cilia on the podocytes are subjected to a stronger bending force. Thus, the disappearance of the primary cilia presumably prevents the entry of excessive calcium-ions via the cilium-associated polycystin complexes and the disturbance of intracellular signaling cascades in mature podocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.