Trial reportPsychopharmacology2010
Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males.
Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Dopamine Depletion Reduces Food-Related Reward Activity Independent of BMI.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Age moderates the effect of acute dopamine depletion on passive avoidance learning.Pharmacology, biochemistry, and behavior · 2015Trial
- Gender differences in clinical outcomes for cocaine dependence: randomized clinical trials of behavioral therapy and disulfiram.Drug and alcohol dependence · 2014Trial
- Dopaminergic stimulation increases selfish behavior in the absence of punishment threat.Psychopharmacology · 2014Trial
- Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heat.European journal of applied physiology · 2013Trial
- Reliance on habits at the expense of goal-directed control following dopamine precursor depletion.Psychopharmacology · 2012Trial
- Nucleus accumbens DRD2 receptor agonism attenuates escape behavior.Frontiers in neuroscience · 2026Article
- Article
- Activity in the Dorsomedial Striatum Underlies Serial Reversal Learning Performance Under Probabilistic Uncertainty.Biological psychiatry global open science · 2023Article
- Cognitive flexibility assessment with a new Reversal learning task paradigm compared with the Wisconsin card sorting test exploring the moderating effect of gender and stress.Psychological research · 2023Article
- Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects.Current behavioral neuroscience reports · 2022Article
- Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- GABA Supplementation Negatively Affects Cognitive Flexibility Independent of Tyrosine.Journal of clinical medicine · 2021Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- Learned avoidance requires VTA KOR-mediated reductions in dopamine.Neuropharmacology · 2020Article
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.Neuroscience · 2017Review
- Cardiac Concomitants of Feedback and Prediction Error Processing in Reinforcement Learning.Frontiers in neuroscience · 2017Article
- The rat's not for turning: Dissociating the psychological components of cognitive inflexibility.Neuroscience and biobehavioral reviews · 2015Review
- Sex-dependent effects on tasks assessing reinforcement learning and interference inhibition.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionThe neurotransmitter dopamine has frequently been implicated in reward processing but is also, increasingly, implicated in punishment processing. We have previously shown that both patients with Parkinson's disease and healthy individuals with low dopamine (DA) synthesis are better at reversal learning based on punishment than reward. Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task.
methodsIn a double-blind, placebo-controlled crossover design, we applied the acute tyrosine and phenylalanine depletion (ATPD) procedure to reduce global DA synthesis in 15 female and 14 male subjects. Each subject performed the reward- and punishment-based reversal-learning paradigm.
resultsThere was a significant three-way interaction between ATPD, the valence of the outcome signalling reversal and the gender of the participants. Examination of punishment and reward-based reversals separately revealed that this was driven by a significant improvement in punishment processing in female but not male subjects following DA depletion.
conclusionsReducing DA synthesis in healthy individuals shifted sensitivity of performance from reward to punishment processing. Gender differences in DA synthesis might underlie the selectivity of this effect to female subjects. Such gender biases may go some way towards explaining the gender biases in certain psychiatric disorders such as depression and Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.