Evidence map›Paper›PMID 20495573›Full record

ReviewNature reviews. Cancer2010

Genetic variation in microRNA networks: the implications for cancer research.

Bríd M Ryan, Ana I Robles, Curtis C Harris

Erratum issuedOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 653 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
653citing papers in PubMed, 10 pooled it
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

653 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,257 citations in OpenAlex.

  1. Genetic association between microRNA gene polymorphisms and polycystic ovary syndrome susceptibility: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Pooled it
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  3. Association ofFrontiers in endocrinology · 2023
    Pooled it
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  16. Review
  17. Genetic variability ofRadiology and oncology · 2025
    Article
  18. Review
  19. Article
  20. Article

593 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bríd M RyanCancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892-4258, USA.
Ana I Robles
Curtis C Harris
Center for Cancer Research · USNational Institutes of Health · US

Funding

Molecular Epidemiology of Human Lung CancerZIABC005480 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HARRIS, CURTIS · 2009 to 2012
$3.0M
Intramural NIH HHS ZIA BC005480
6 · The paper itself

Abstract

Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.

Indexed as

Gene Expression Regulation, NeoplasticGene Regulatory NetworksPolymorphism, Single NucleotideAlternative SplicingAnimalsHumansMicroRNAsNeoplasmsMicroRNAs

Identifiers

PMID20495573
PMCPMC2950312
OpenAlexW1971460830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.